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Titolo:
Localized and transient transcription of Hox genes suggests a link betweenpatterning and the segmentation clock
Autore:
Zakany, J; Kmita, M; Alarcon, P; de la Pompa, JL; Duboule, D;
Indirizzi:
Univ Geneva, Dept Zool & Anim Biol, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 nim Biol, CH-1211 Geneva 4, Switzerland Hosp Duran & Reynals, Inst Recerca Oncol, Dept Mol Oncol, Barcelona, SpainHosp Duran & Reynals Barcelona Spain , Dept Mol Oncol, Barcelona, Spain EMBL, Mouse Biol Program, Rome, Italy EMBL Rome ItalyEMBL, Mouse Biol Program, Rome, Italy
Titolo Testata:
CELL
fascicolo: 2, volume: 106, anno: 2001,
pagine: 207 - 217
SICI:
0092-8674(20010727)106:2<207:LATTOH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMITE BOUNDARY FORMATION; LUNATIC FRINGE; DELTA-HOMOLOG; REGULATORY CONTROLS; HOMEOBOX GENE; BODY PLAN; MOUSE; EXPRESSION; COMPLEX; MURINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Duboule, D Univ Geneva, Dept Zool & Anim Biol, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland Univ Geneva Quai Ernest Ansermet 30 Geneva Switzerland 4 rland
Citazione:
J. Zakany et al., "Localized and transient transcription of Hox genes suggests a link betweenpatterning and the segmentation clock", CELL, 106(2), 2001, pp. 207-217

Abstract

During development, Hox gene transcription is activated in presomitic mesoderm with a time sequence that follows the order of the genes along the chromosome. Here, we show that Hoxd1 and other Hox genes display dynamic stripes of expression within presomitic mesoderm. The underlying transcriptionalbursts may reflect the mechanism that coordinates Hox gene activation withsomitogenesis. This mechanism appears to depend upon Notch signaling, as mice deficient for RBPJk, the effector of the Notch pathway, showed severelyreduced Hoxd gene expression in presomitic mesoderm. These results suggesta molecular link between Hox gene activation and the segmentation clock. Such a linkage would efficiently keep in phase the production of novel segments with their morphological specification.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:29:43