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Titolo:
Local delivery of paclitaxel using the double-balloon perfusion catheter before stenting in the porcine coronary artery
Autore:
Oberhoff, M; Herdeg, C; Al Ghobainy, R; Cetin, S; Kuttner, A; Horch, B; Baumbach, A; Karsch, KR;
Indirizzi:
Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England Univ Bristol Bristol Avon England BS2 8HW Bristol BS2 8HW, Avon, England Univ Tubingen, Dept Med, Div Cardiol, Tubingen, Germany Univ Tubingen Tubingen Germany Dept Med, Div Cardiol, Tubingen, Germany
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 4, volume: 53, anno: 2001,
pagine: 562 - 568
SICI:
1522-1946(200108)53:4<562:LDOPUT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE CELL-PROLIFERATION; NEOINTIMAL RESPONSE; DRUG DELIVERY; IN-VIVO; RESTENOSIS; ANGIOPLASTY; TAXOL; INJURY; MODEL; EFFICACY;
Keywords:
angioplasty; pig; restenosis; paclitaxel; local drug delivery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Oberhoff, M Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England Univ Bristol Bristol Avon England BS2 8HW 8HW, Avon, England
Citazione:
M. Oberhoff et al., "Local delivery of paclitaxel using the double-balloon perfusion catheter before stenting in the porcine coronary artery", CATHET C IN, 53(4), 2001, pp. 562-568

Abstract

Paclitaxel is a new cancer chemotherapeutic agent that has been approved for clinical use in patients with a variety of different cancers. Paclitaxelinhibits cell proliferation by an action on microtubules. The aim of this study was to evaluate the safety and efficacy of locally delivered paclitaxel after coronary stent implantation. A novel double-balloon perfusion catheter was used to deliver the drug locally in the pig coronary artery. Twenty-seven domestic pigs underwent stent implantation of the left anterior descending artery. In the treatment group (n = 11), paclitaxel (10 ml;10 mu mol/l) was delivered using the double-balloon perfusion catheter prior to stent implantation. The control group received stent implantation only (n = 16). The animals were sacrificed 4 weeks later. Vessels were perfusion-fixed and morphometric analysis was performed using conventional techniques. In addition, the extent of injury was determined at each stent-strut area. Correlation of local injury and neointimal thickness was evaluated by linear regression. Neointimal thickness (paclitaxel 1.0 +/- 0.4 vs. control 0.7 +/- 0.3 mm), neointimal area (paclitaxel 4.1 +/- 2.2 vs. control 2.4 +/- 1.1 mm, and the lumen area (paclitaxel 2.1 +/- 1.9 vs. control 2.5 +/- 0.9 mm didnot show significant differences between both groups. Medial area (3.3 +/-2.3 vs. 1.6 +/- 0.4 mm was larger in the vessels treated with paclitaxel (P < 0.05). Linear regression failed to show any difference in the response to injury between the two groups. Local delivery of paclitaxel with the double-balloon-perfusion catheter did not reduce neointima formation followingstent implantation in native pig coronary arteries. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:15:02