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Titolo:
Hemodynamic characterization of arterialized and nonarterialized liver transplants in the rat
Autore:
Wong, J; Zhang, YK; Lee, SS;
Indirizzi:
Univ Calgary, Gastroenterol Res Grp, Liver Unit, Calgary, AB, Canada Univ Calgary Calgary AB Canada Res Grp, Liver Unit, Calgary, AB, Canada
Titolo Testata:
CANADIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 7, volume: 15, anno: 2001,
pagine: 435 - 440
SICI:
0835-7900(200107)15:7<435:HCOAAN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; HEPATIC-ARTERY; HYPERKINETIC CIRCULATION; SYSTEMIC HEMODYNAMICS; CIRRHOTIC RATS; RECONSTRUCTION; ALLOGRAFT; DISEASE;
Keywords:
cardiovascular; collaterals; hepatic allograft; hyperemia; splanchnic hyperemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SS 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada 3330 Hosp Dr NW Calgary AB Canada T2N 4N1 ary, AB T2N 4N1, Canada
Citazione:
J. Wong et al., "Hemodynamic characterization of arterialized and nonarterialized liver transplants in the rat", CAN J GASTR, 15(7), 2001, pp. 435-440

Abstract

Persistent hyperkinetic circulation after liver transplantation has been described in humans, but similar changes have not been well characterized inthe rat model. This study aimed to investigate the hemodynamics of the systemic and splanchnic circulations in both arterialized and nonarteriatized hepatic allografts. Orthotopic liver transplantation was performed in four groups of Sprague-Dawley rats. Group A comprised sham-operated rats with hepatic artery ligation that did not receive transplants; group B comprised rats that received transplants without arterialization; group C comprised sham-operated rats with intact hepatic artery that did not receive transplants; and group D comprised rats that received transplants with arterialization. Blood flow measurements were performed three weeks after the surgical procedure, using the radioactive microsphere method. The results showed that rats that received transplants exhibited a significantly higher cardiac index and lower systemic vascular resistance than the control rats. Splanchnichyperemia was also present with increased mesenteric blood flow. However, there was no difference in hemodynamics between rats that received arterialized transplants and those that received nonarterialized transplants. Arterial collateral vessels from adjacent tissues were observed in the nonarterialized grafts; this was confirmed histologically. It is concluded that ratsthat undergo orthotopic liver transplantation exhibit hyperdynamic circulation, regardless of the arterial reconstruction procedure, possibly due to extensive collateral formation in the hepatosplanchnic circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:48:20