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Titolo:
Anticholinesterase effect of eserine (physostigmine) in fish and crustacean species
Autore:
Monserrat, JM; Bianchini, A;
Indirizzi:
Fundacao Univ Rio Grande, Dept Ciencias Fisiol, Lab Zoofisiol, BR-96201900Rio Grande, RS, Brazil Fundacao Univ Rio Grande Rio Grande RS Brazil BR-96201900 BCe, RS, Brazil
Titolo Testata:
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
fascicolo: 1, volume: 44, anno: 2001,
pagine: 63 - 68
SICI:
1516-8913(200103)44:1<63:AEOE(I>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL PARATHION; ACUTE TOXICITY; ACETYLCHOLINESTERASE; INSECTICIDES; INHIBITION; TELEOSTEI;
Keywords:
eserine; physostigmine; acetylcholinesterase; fish; silverside fish; crustacean;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Monserrat, JM Fundacao Univ Rio Grande, Dept Ciencias Fisiol, Lab Zoofisiol, Caixa Postal 474, BR-96201900 Rio Grande, RS, Brazil Fundacao Univ Rio Grande Caixa Postal 474 Rio Grande RS Brazil BR-96201900 BC
Citazione:
J.M. Monserrat e A. Bianchini, "Anticholinesterase effect of eserine (physostigmine) in fish and crustacean species", BRAZ ARCH B, 44(1), 2001, pp. 63-68

Abstract

The kinetic characteristic (K-m) of cholinesterase from the crab Chasmagnathus granulata, the shrimp Farfantepenaeus paulensis and the fish Odontesthes bonaeriensis were compared and correlated with the anticholinesterasic effect of eserine (physostigmine). For the crustaceans, the estimated K-m values were about 5-8 times higher than that estimated for the fish (0.04 mM). In the crab and the shrimp, the concentration of eserine which inhibited 50% of cholinesterase activity (IC50) was estimated as 5.33x10(-4) and 4.33x10(-4) mM,, respectively. In both cases, it was significantly higher (P < 0.05) than that estimated for the fish larvae (7.43x10(-5) mM). A high K-m could reflect a lower affinity of the cholinesterase for its natural substrate, acetylcholine, or for substrate analogues such as carbamates and organophosphorous pesticides. If we consider the IC50 for eserine as an index ofenzyme susceptibility to pesticide inhibition, the cholinesterase from thefish larvae may be a better useful tool in assays for pesticide biomonitoring than that from crustacean species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:52:21