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Titolo:
Estrogen receptor gene polymorphism and bone mineral density in postmenopausal Chinese women
Autore:
Lau, EMC; Young, RP; Lam, V; Li, M; Woo, J;
Indirizzi:
Chinese Univ Hong Kong, Lek Yuen Hlth Ctr, Dept Community & Family Med, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Univ Auckland, Auckland Hosp, Dept Med, Auckland 1, New Zealand Univ Auckland Auckland New Zealand 1 , Dept Med, Auckland 1, New Zealand Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
BONE
fascicolo: 1, volume: 29, anno: 2001,
pagine: 96 - 98
SICI:
8756-3282(200107)29:1<96:ERGPAB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D; JAPANESE WOMEN; PREMENOPAUSAL; ALLELES;
Keywords:
estrogen receptor gene (ERG); bone mineral density (BMD); postmenopausal Chinese women; dual-energy X-ray; absorptiometry (DEXA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Lau, EMC Chinese Univ Hong Kong, Lek Yuen Hlth Ctr, Dept Community & Family Med, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China R China
Citazione:
E.M.C. Lau et al., "Estrogen receptor gene polymorphism and bone mineral density in postmenopausal Chinese women", BONE, 29(1), 2001, pp. 96-98

Abstract

PvuII and XbaI restriction fragment length polymorphisms (RFLPs) for the estrogen receptor gene (ERG) and its relation to bone mineral density (BMD) were examined in 454 postmenopausal Chinese women, aged 55-79 years. The RFLPs were represented as P or p (PvuII) and X or x (XbaI), with capital letters signifying the absence of and small letters the presence of restrictionsites. There was no significant difference in BMD between the PP, Pp, and pp genotypes. However, women of the XX genotype had significantly higher BMD at the spine than women of the Xx or xx genotype. The magnitude of the difference in BMI) was 80% of a standard deviation (SD) for BMD in elderly women and 40% of a SD in postmenopausal women. There was no statistically significant interaction between the PvuII genotype and the XbaI genotype in determining BMI). We conclude that postmenopausal Chinese women who were homozygous for the XX genotype had slightly higher BMD than the others. However, the difference in BMD was small and was unlikely to have any clinical significance. The ERG is not a major determinant of BMD in Chinese women in Hong Kong. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:22:02