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Titolo:
Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria
Autore:
Rolo, AP; Oliveira, PJ; Moreno, AJM; Palmeira, CM;
Indirizzi:
Univ Coimbra, Dept Zool, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004517 iol, P-3004517 Coimbra, Portugal
Titolo Testata:
BIOSCIENCE REPORTS
fascicolo: 1, volume: 21, anno: 2001,
pagine: 73 - 80
SICI:
0144-8463(200102)21:1<73:CIAPIO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; BILE-ACIDS; CYCLOSPORINE-A; CHOLESTASIS; MECHANISM; MEMBRANE; MODULATION; INDUCTION; CALCIUM; GLYCOCHENODEOXYCHOLATE;
Keywords:
mitochondria; permeability; chenodeoxycholic acid; calcium; membrane potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Palmeira, CM Univ Coimbra, Dept Zool, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3004517 7 Coimbra, Portugal
Citazione:
A.P. Rolo et al., "Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria", BIOSCI REP, 21(1), 2001, pp. 73-80

Abstract

Several reports support the concept that bile acids may be cytotoxic during cholestatic disease process by causing mitochondrial dysfunction. Here wereport additional data and findings aimed at a better understanding of theinvolvement of the permeability transition pore (PTP) opening in bile acids toxicity. The mitochondrial PTP is implicated as a mediator of cell injury and death in many situations. In the presence of calcium and phosphate, chenodeoxycholic acid (CDCA) induced a permeability transition in freshly isolated rat liver mitochondria, characterized by membrane depolarization, release of matrix calcium, and osmotic swelling. All these events were blocked by cyclosporine A (CyA) and the calcium uniporter inhibitor ruthenium red(RR). The results suggest that CDCA increases the sensitivity of isolated mitochondria in vitro to the calcium-dependent induction of the PTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:19:07