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Titolo:
Promoter characterization and expression of the gene coding for the human GM2 activator protein
Autore:
Beccari, T; Balducci, C; Aisa, MC; Della Fazia, MA; Servillo, G; Orlacchio, A;
Indirizzi:
Univ Perugia, Dipartimento Sci Biochim & Biotecnol Mol, I-06126 Perugia, Italy Univ Perugia Perugia Italy I-06126 Biotecnol Mol, I-06126 Perugia, Italy
Titolo Testata:
BIOSCIENCE REPORTS
fascicolo: 1, volume: 21, anno: 2001,
pagine: 55 - 62
SICI:
0144-8463(200102)21:1<55:PCAEOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTATION; IDENTIFICATION; LOCALIZATION; CHROMOSOME-3; VARIANT; AB;
Keywords:
GM2 activator protein; GM2 ganglioside; gene expression; promoter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Beccari, T Univ Perugia, Dipartimento Sci Biochim & Biotecnol Mol, I-06126Perugia, Italy Univ Perugia Perugia Italy I-06126 ol, I-06126 Perugia, Italy
Citazione:
T. Beccari et al., "Promoter characterization and expression of the gene coding for the human GM2 activator protein", BIOSCI REP, 21(1), 2001, pp. 55-62

Abstract

Genomic clones of the human GM2 activator protein have been isolated and analyzed. The 5 ' region of the gene demonstrated promoter activity as ascertained by its ability to drive luciferase gene expression in transfected COS cells. This sequence contains GC rich region and several putative promoter elements were present, including Spl, AP2, cAMP-responsive element, and B-cell-specific activating protein. Analysis of tissue distribution of the GM2 activator protein gene revealed tissue-specific variations in transcriptlevels. Placenta, bone marrow, mammary gland, bladder, lymph node, and spleen had the highest mRNA levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:24:45