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Titolo:
New aspects of physiological and pathophysiological functions of adenosineA(2A) receptor in basal ganglia
Autore:
Kase, H;
Indirizzi:
Kyowa Hakko Kogyo Co Ltd, Div Pharmaceut Res & Dev, Chiyoda Ku, Tokyo 1008185, Japan Kyowa Hakko Kogyo Co Ltd Tokyo Japan 1008185 da Ku, Tokyo 1008185, Japan
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 7, volume: 65, anno: 2001,
pagine: 1447 - 1457
SICI:
0916-8451(200107)65:7<1447:NAOPAP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RAT STRIATUM; ENDOGENOUS ADENOSINE; MEDIATED MODULATION; SYNAPTIC TRANSMISSION; LOCOMOTOR IMPAIRMENT; ADENINE-NUCLEOTIDES; EXTRACELLULAR ATP; CAUDATE-NUCLEUS; MESSENGER-RNA;
Keywords:
adenosine; receptor; movement; basal ganglia; neuromodulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Kase, H Kyowa Hakko Kogyo Co Ltd, Div Pharmaceut Res & Dev, Chiyoda Ku, 1-60-1 Ohtemachi, Tokyo 1008185, Japan Kyowa Hakko Kogyo Co Ltd 1-60-1 Ohtemachi Tokyo Japan 1008185 pan
Citazione:
H. Kase, "New aspects of physiological and pathophysiological functions of adenosineA(2A) receptor in basal ganglia", BIOS BIOT B, 65(7), 2001, pp. 1447-1457

Abstract

There is now growing interest in the functional role of adenosine A(2A) receptors. Their distribution within the brain is restricted in the basal ganglia, particularly abundant in the striatum, which are thought to play a crucial role in the control of motor behavior. Indeed, newly developed A(2A) receptor selective antagonists have a profound influence on motor functions, with anti-Parkinsonian activities in several animal models. Striatal spiny neurons serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. The GABA releasing projection neurons represent the A(2A) receptor-mediated main target of adenosine. The GABAergic synaptic neurotransmission is regulated by adenosine via A(2A) receptors on the presynaptic terminals. Blockade of this modulatory function by A(2A) antagonists could repair striatopallidal abnormal neuronal activities provoked by striatal dopamine depletion in the Parkinsonian state. A(2A) receptor antagonists provide a novel therapeutic potential for the treatment of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:46:23