Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis and QSAR studies of 4-substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents
Autore:
Desai, B; Sureja, D; Naliapara, Y; Shah, A; Saxena, AK;
Indirizzi:
Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India Saurashtra UnivRajkot Gujarat India 360005 Rajkot 360005, Gujarat, India Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India Cent Drug Res Inst Lucknow Uttar Pradesh India 226001 ttar Pradesh, India
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 8, volume: 9, anno: 2001,
pagine: 1993 - 1998
SICI:
0968-0896(200108)9:8<1993:SAQSO4>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBERCULOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Saxena, AK Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India Saurashtra Univ Rajkot Gujarat India 360005 05, Gujarat, India
Citazione:
B. Desai et al., "Synthesis and QSAR studies of 4-substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents", BIO MED CH, 9(8), 2001, pp. 1993-1998

Abstract

Synthesis and QSAR studies of the title compounds have resulted in the identification of structural and physicochemical parameters (MR, sigma (o), sigma (m), sigma (p)) contributing to antitubercular activity. Among these, carbamoyl phenyl ring substituted at 3 and 4 position with NO2 group or 2 position with Cl or OCH3 group shows > 90% inhibition against H37R nu comparable to other substituted phenyls. (C) 2001 Elsevier Science Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:05:24