Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Estrogen-induced gonadal sex reversal in the tammar wallaby
Autore:
Coveney, D; Shaw, G; Renfree, MB;
Indirizzi:
Univ Melbourne, Dept Zool, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 2, volume: 65, anno: 2001,
pagine: 613 - 621
SICI:
0006-3363(200108)65:2<613:EGSRIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROUT ONCORHYNCHUS-MYKISS; PRIMORDIAL GERM-CELLS; MOUSE FETAL TESTIS; MONODELPHIS-DOMESTICA; MACROPUS-EUGENII; PATHOLOGICAL RESEARCH; MAMMALIAN GONAD; GENE-EXPRESSION; SERTOLI CELLS; POUCH YOUNG;
Keywords:
developmental biology; early development; estradiol; ovary; testis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Renfree, MB Univ Melbourne, Dept Zool, Melbourne, Vic 3010, Australia UnivMelbourne Melbourne Vic Australia 3010 c 3010, Australia
Citazione:
D. Coveney et al., "Estrogen-induced gonadal sex reversal in the tammar wallaby", BIOL REPROD, 65(2), 2001, pp. 613-621

Abstract

Estrogens have a feminizing effect on gonadal differentiation in fish, amphibians, reptiles, and birds. However, the role of estrogen during gonadal differentiation in mammals is less clear. We investigated the effect of estrogen on gonadal differentiation of male tammar wallabies. Male pouch youngwere treated orally with estradiol benzoate or oil from the day of birth, before seminiferous cords develop, to Day 25 postpartum and were killed at Day 50 postpartum. In all estrogen-treated neonates, a decrease in gonadal volume, volume of the seminiferous cords, thickness of the tunica albuginea, and number of germ cells was found. The stage of treatment affected the magnitude of the response. Two of three male young born prematurely after 25days of gestation and treated subsequently with estradiol had ovary-like gonads, with well-developed cortical and medullary regions and primordial follicle formation. Furthermore, at Day 50 postpartum, many (21 %) of the germ cells in these sex-reversed ovaries were in the leptotene and zygotene stages of meiosis, similar to female germ cells at the same stage of development. In the other males born on Day 26 of gestation or later, estradiol treatment from the day of birth caused development of dysgenetic testes, with abnormal Sertoli cells, atrophy of the seminiferous tubules and tunica albuginea, and absence of meiotic germ cells. in this marsupial, therefore, estradiol can induce either partial or complete transformation of the male gonads into an ovary with meiotic germ cells. These results confirm that estrogen can inhibit early testicular development, and that testis determinationoccurs during a narrow window of time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 20:44:51