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Titolo:
Repeated intermittent administration of psychomotor stimulant drugs altersthe acquisition of pavlovian approach behavior in rats: Differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine ("ecstasy")
Autore:
Taylor, JR; Jentsch, JD;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 , Dept Psychiat, New Haven, CT 06508 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 50, anno: 2001,
pagine: 137 - 143
SICI:
0006-3223(20010715)50:2<137:RIAOPS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
REWARD-RELATED STIMULI; ANTERIOR CINGULATE CORTEX; NUCLEUS-ACCUMBENS CORE; PREFRONTAL CORTEX; CONDITIONED REINFORCEMENT; 6-HYDROXYDOPAMINE LESIONS; DOPAMINE TRANSMISSION; REPEATED PRETREATMENT; BASOLATERAL AMYGDALA; 2ND-ORDER SCHEDULE;
Keywords:
sensitization; dopamine; nucleus accumbens; amygdala; incentive motivation; drug addiction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, JR Yale Univ, Sch Med, Dept Psychiat, CMHC-34 Pk St, New Haven, CT06508 USA Yale Univ CMHC-34 Pk St New Haven CT USA 06508 en, CT 06508 USA
Citazione:
J.R. Taylor e J.D. Jentsch, "Repeated intermittent administration of psychomotor stimulant drugs altersthe acquisition of pavlovian approach behavior in rats: Differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine ("ecstasy")", BIOL PSYCHI, 50(2), 2001, pp. 137-143

Abstract

Background: Psychomotor stimulant drugs can produce long-lasting changes in neurochemistry and behavior after multiple closes. In particular, neuroadaptations within corticolimbic brain structures that mediate incentive learning and motivated behavior have been demonstrated after chronic exposure to cocaine, d-amphetamine, and 3,4-methylenedioxymethamphetamine (MDMA). As stimulus-reward learning is likely relevant to addictive behavior (i.e., augmented conditioned reward and stimulus control of behavior), we have investigated whether prior repeated administration of psychomotor stimulant drugs of abuse, including cocaine, d-amphetamine, or MDMA, would affect the acquisition of Pavlovian approach behavior. Methods: Water-deprived rats were tested for the acquisition of Pavlovian approach behavior after 5 days treatment with cocaine (15-20 mg/kg once or twice daily), d-amphetamine (2.5 mg/kg once or twice daily), or MDMA (2.5 mg/kg twice daily) followed by a 7-day, drug-free period. Results: Prior repeated treatment with cocaine or d-amphetamine produced asignificant enhancement of acquisition of Pavlovian approach behavior, indicating accelerated stimulus-reward learning, whereas MDMA administration produced increased inappropriate responding, indicating impulsivity. Abnormal drug-induced approach behavior was found to persist throughout the testing period. Conclusions: These studies demonstrate that psychomotor stimulant-induced sensitization can produce long-term alterations in stimulus-reward learningand impulse control that may contribute to the compulsive drug taking thattypifies addiction. (C) 2001 Society of Biological Psychiatry.

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Documento generato il 05/04/20 alle ore 22:57:52