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Titolo:
Three-dimensional mapping of temporo-limbic regions and the lateral ventricles in schizophrenia: Gender effects
Autore:
Narr, KL; Thompson, PM; Sharma, T; Moussai, J; Blanton, R; Anvar, B; Edris, A; Krupp, R; Rayman, J; Khaledy, M; Toga, AW;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuroimaging,Div Brain Mapping, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Inst Psychiat, Sect Cognit Psychopharmacol, London, England Inst PsychiatLondon England ct Cognit Psychopharmacol, London, England
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 50, anno: 2001,
pagine: 84 - 97
SICI:
0006-3223(20010715)50:2<84:TMOTRA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD-ONSET SCHIZOPHRENIA; FIRST-EPISODE SCHIZOPHRENIA; HUMAN BRAIN; PLANUM TEMPORALE; PROBABILISTIC ATLAS; HIPPOCAMPAL VOLUME; SULCAL VARIABILITY; MONOZYGOTIC TWINS; SYLVIAN FISSURE; CORPUS-CALLOSUM;
Keywords:
MRI; hippocampus; ventricles; amygdala; asymmetry; morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Toga, AW Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuroimaging,Div Brain Mapping, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
K.L. Narr et al., "Three-dimensional mapping of temporo-limbic regions and the lateral ventricles in schizophrenia: Gender effects", BIOL PSYCHI, 50(2), 2001, pp. 84-97

Abstract

Background: Local alterations in morphological parameters are poorly characterized in several brain regions widely implicated in schizophrenia neuropathology. Methods: Surface-based anatomical modeling was applied to magnetic resonance data to obtain three-dimensional (3D) average anatomical maps and measures of location, shape, asymmetry, and volume for the lateral ventricles, hippocampus, amygdala, and superior temporal gyrus in schizophrenic (n = 25; 15 male) and normal subjects (n = 28; 15 male) matched for demographic variables, For all regions, intra-group variability was visualized and group differences assessed statistically to discriminate local alterations in anatomy across sex and diagnosis. Results: Posterior hippocampal volumes, lengths, and widths were reduced in patients. The right amygdala showed volume increases in schizophrenia patients versus controls, Ventricular enlargements, pronounced in the left hemisphere, occurred in the superior and lateral dimensions in patients, and these effects interacted with gender. Superior horn anterior extremes, inferior horn volumes, and hippocampal asymmetries exhibited gender effects. Significant group differences were absent in superior temporal gyrus parameters. Finally, regional variability profiles differed across groups. Conclusions: Clear morphometric differences of the lateral ventricles, hippocampus, and amygdala indicate regional displacements and shape distortions in several functional systems in schizophrenia. Alterations in these structures as mapped in 3D may, provide the foundation for establishing brain abnormalities not previously defined at such a local level. (C) 2001 Societyof Biological Psychiatry.

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Documento generato il 19/01/20 alle ore 00:29:06