Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Coenzymes Q(9) and Q(10), vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing
Autore:
Battino, M; Bompadre, S; Leone, L; Villa, RF; Gorini, A;
Indirizzi:
Univ Ancona, Sch Med, Inst Biochem, I-60100 Ancona, Italy Univ Ancona Ancona Italy I-60100 ed, Inst Biochem, I-60100 Ancona, Italy Univ Ancona, Sch Med, Inst Biomed Sci, I-60100 Ancona, Italy Univ Ancona Ancona Italy I-60100 Inst Biomed Sci, I-60100 Ancona, Italy Univ Pavia, Dept Physiol Pharmacol Cellular Mol Sci, Div Pharmacol & Pharmacol Biotechnol, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 harmacol Biotechnol, I-27100 Pavia, Italy
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 6, volume: 382, anno: 2001,
pagine: 925 - 931
SICI:
1431-6730(200106)382:6<925:CQAQVE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; NONSYNAPTIC MITOCHONDRIA; LIPID-PEROXIDATION; OXIDATIVE STRESS; XYLENOL ORANGE; BRAIN-REGIONS; HUMAN PLASMA; DIETARY-FAT; HIPPOCAMPUS;
Keywords:
brain mitochondrial heterogeneity; coenzyme Q ratio; oxidative stress; vitamin E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Battino, M Univ Ancona, Sch Med, Inst Biochem, I-60100 Ancona, Italy Univ Ancona Ancona Italy I-60100 ochem, I-60100 Ancona, Italy
Citazione:
M. Battino et al., "Coenzymes Q(9) and Q(10), vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing", BIOL CHEM, 382(6), 2001, pp. 925-931

Abstract

Great attention has been devoted both to ageing phenomena at the mitochondrial level and to the antioxidant status of membrane structures. These kinds of investigations are difficult to perform in the brain because of its heterogeneity. It is known that synaptic heavy mitochondria (HM) may represent an aged mitochondrial population characterized by a partial impairment oftheir typical mitochondrial function. We arranged a novel system requiringno extraction procedure, very limited handling of the samples and their direct injection into the HPLC apparatus, to carry out, for the first time, asystematic and concomitant determination of vitamin E, Coenzyme Q(9) (CoQ(9)) and Coenzyme Q(10) (CoQ(10)) contents in rat brain mitochondria. The trends found for CoQ(9) and CoQ(10) levels in synaptic and non-synaptic occipital cerebral cortex mitochondria during rat ageing are consistent with previous data. Hydroperoxides (HP) differed with age and it was confirmed thatin the HM fraction the summation of contributions results in an oxidatively jeopardized subpopulation. We found that vitamin E seems to increase withage, at least in non-synaptic free (FM) and synaptic light (LM) mitochondria, while it was inclined to remain substantially constant in HM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:27:15