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Titolo:
Enhanced free radical scavenging and decreased lipid peroxidation in the rat fetal brain after treatment with ethyl docosahexaenoate
Autore:
Green, P; Glozman, S; Weiner, L; Yavin, E;
Indirizzi:
Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel Weizmann InstSci Rehovot Israel IL-76100 Chem, IL-76100 Rehovot, Israel
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 3, volume: 1532, anno: 2001,
pagine: 203 - 212
SICI:
1388-1981(20010629)1532:3<203:EFRSAD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-PARAMAGNETIC-RESONANCE; POLYUNSATURATED FATTY-ACID; CEREBRAL-ISCHEMIA; ANTIOXIDANT CAPACITY; CYCLIC VOLTAMMETRY; REPERFUSION INJURY; OXIDATIVE STRESS; LIVER; PROSTAGLANDIN; ACCUMULATION;
Keywords:
docosahexaenoic acid; fetal brain; lipid peroxidation; free radical; 5,5 '-dimethyl-1-pyrroline N-oxide; quinone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Yavin, E Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
P. Green et al., "Enhanced free radical scavenging and decreased lipid peroxidation in the rat fetal brain after treatment with ethyl docosahexaenoate", BBA-MOL C B, 1532(3), 2001, pp. 203-212

Abstract

In order to explore possible mechanisms to explain previously observed decreases in fetal brain lipid peroxidation (LPO) following intraamniotic administration of ethyl docosahexaenoate (Et-DHA) to near term fetuses, the hydroxyl radical trapping capacity of Et-DHA treated fetal brain preparations was compared to control ethyl oleate injected fetuses by electron spin resonance using 5,5'-dimethyl-1-pyrroline N-oxide (DMPO) probe. Lipid extracts from control brains showed little hydroxyl radical scavenging activity, whereas those from the Et-DHA injected animals exhibited an almost 70% decrease in the amount of DMPO-OH adducts. A marked decrease (58%) in LPO formation was noticed in the Et-DHA treated animals compared to controls. The Et-DHA treatment related trapping capacity resided in the phospholipid fraction of the lipid extract, which was enriched in both docosahexaenoic acid and aminophospholipid contents. The decreased LPO production, as well as increased production of prostaglandin E-2 and nitric oxide by the fetal brain following Et-DHA administration, could be mimicked by a synthetic quinone possessing both hydroxyl radical producing and LPO propagation inhibiting properties. The data are consistent with the possibility that the neuroprotectiveeffect of Et-DHA might be due to possible free radical scavenging ability of the brain tissue and interference with LPO propagation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:46:53