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Titolo:
Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein
Autore:
Kojima, K; Abe-Dohmae, S; Arakawa, R; Murakami, I; Suzumori, K; Yokoyama, S;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Biochem 1, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Obstet & Gynecol, Mizuho Ku, Nagoya, Aichi4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 , Nagoya, Aichi4678601, Japan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 3, volume: 1532, anno: 2001,
pagine: 173 - 184
SICI:
1388-1981(20010629)1532:3<173:PIACLR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING CASSETTE TRANSPORTER-1; HORMONE REPLACEMENT THERAPY; TANGIER-DISEASE PATIENTS; POSTMENOPAUSAL WOMEN; CHOLESTEROL EFFLUX; PLASMA-MEMBRANE; INTRACELLULAR CHOLESTEROL; A-I; CELLS; MACROPHAGES;
Keywords:
high density lipoprotein; apolipoprotein A-I; estrogen; progesterone; cholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoyama, S Nagoya City Univ, Sch Med, Dept Biochem 1, Mizuho Ku, Kawasumi1,Mizuho Cho, Nagoya, Aichi 4678601, Japan Nagoya City Univ Kawasumi 1,Mizuho Cho Nagoya Aichi Japan 4678601
Citazione:
K. Kojima et al., "Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein", BBA-MOL C B, 1532(3), 2001, pp. 173-184

Abstract

In order to investigate the mechanism for female gonadal hormones to regulate the plasma high-density lipoprotein (HDL) level, the effect of 17 beta -estradiol and progestogens was examined in vitro on the assembly of HDL byfree apolipoprotein A-I (apoA-I) with cellular cholesterol and phospholipid. ApoA-I generated HDL particles by removing cholesterol and phospholipid from human fibroblasts, MRC-5. While 17 beta -estradiol did not influence this reaction, progesterone suppressed the removal by apoA-I of both cholesterol and phospholipid, with the extent of the inhibition more for cholesterol than phospholipid. Three other synthetic progestogens showed the similarinhibitory effect on the cellular cholesterol release. Cellular cholesterol de novo-synthesized from mevalonolactone entered more into the acyl-esterified cholesterol compartment and less to the unesterified compartment in the presence of progesterone. On the other hand, progesterone did not influence the overall mass ratio of free and esterified cholesterol in the cell. Cell-surface cholesterol was also uninfluenced by progesterone, when probedby extracellular cholesterol oxidase reaction or by diffusion-mediated cellular cholesterol release to cyclodextrin. Neither caveolin-1 nor ABCA1 expression was influenced by progesterone. Progesterone, thus seems primarily to alter the specific intracellular cholesterol compartment that is relatedto the apoA-I-mediated HDL assembly. This mechanism might contribute to the decrease of plasma HDL by administration of progestogen in women under hormone replacement therapy. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:27:21