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Titolo:
Peripheral cell loss related to calcium binding protein immunocytochemistry in the dorsal cochlear nucleus in CBA/CaJ mice during aging
Autore:
Idrizbegovic, E; Viberg, A; Bogdanovic, N; Canlon, B;
Indirizzi:
Huddinge Univ Hosp, Karolinska Inst, Dept Audiol, S-14186 Huddinge, SwedenHuddinge Univ Hosp Huddinge Sweden S-14186 iol, S-14186 Huddinge, Sweden Karolinska Inst, Dept Physiol & Pharmacol, S-10521 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10521 acol, S-10521 Stockholm, Sweden Karolinska Inst, NEUROTEC, Geriatr Sect, S-10521 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10521 Sect, S-10521 Stockholm, Sweden
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 132 - 139
SICI:
1420-3030(200105/06)6:3<132:PCLRTC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; INFERIOR COLLICULUS; CYTOCHROME-OXIDASE; NEURONS; RAT; PARVALBUMIN; YOUNG; IMMUNOREACTIVITY; MORPHOLOGY; C57BL/6J;
Keywords:
hair cells; spiral ganglia neurons; parvalbumin; calretinin; calbindin quantification; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Idrizbegovic, E Huddinge Univ Hosp, Karolinska Inst, Dept Audiol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 dinge, Sweden
Citazione:
E. Idrizbegovic et al., "Peripheral cell loss related to calcium binding protein immunocytochemistry in the dorsal cochlear nucleus in CBA/CaJ mice during aging", AUDIOL NEUR, 6(3), 2001, pp. 132-139

Abstract

The influence of cochlear hair cell and spiral ganglia neuron loss on calcium binding protein immunoreactivity (calretinin, parvalbumin and calbindin) in the dorsal and posteroventral cochlear nuclei (DCN and PVCN) in CBA/ CaJ (CBA) mice during aging (1-39 months) was determined. Since calcium binding proteins have buffering properties against calcium overload, they may have a protective role during aging. It is shown that the percentage of calretinin- and parvalbumin-immunopositive neurons in the DCN showed a statistically significant positive correlation with inner hair cell loss, outer hair cell loss, and spiral ganglion cell loss. A correlation was also found between aging and the auditory periphery, and calcium binding proteins in theDCN. These findings Imply that the pathophysiological state of the auditory periphery may influence the neuronal homeostasis in the dorsal cochlear nucleus. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:46:40