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Titolo:
Theophylline toxicokinetics in premature newborns
Autore:
Lowry, JA; Jarrett, RV; Wasserman, G; Pettett, G; Kauffman, RE;
Indirizzi:
Childrens Mercy Hosp, Div Clin Pharmacol & Toxicol, Kansas City, MO 64108 USA Childrens Mercy Hosp Kansas City MO USA 64108 , Kansas City, MO 64108 USA Childrens Mercy Hosp, Sect Neonatol, Kansas City, MO 64108 USA Childrens Mercy Hosp Kansas City MO USA 64108 , Kansas City, MO 64108 USA Univ Missouri, Dept Pediat, Kansas City, MO 64110 USA Univ Missouri Kansas City MO USA 64110 Pediat, Kansas City, MO 64110 USA Univ Missouri, Dept Pharmacol, Kansas City, MO 64110 USA Univ Missouri Kansas City MO USA 64110 armacol, Kansas City, MO 64110 USA St Lukes Reg Med Ctr, Boise, ID USA St Lukes Reg Med Ctr Boise ID USASt Lukes Reg Med Ctr, Boise, ID USA
Titolo Testata:
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
fascicolo: 8, volume: 155, anno: 2001,
pagine: 934 - 939
SICI:
1072-4710(200108)155:8<934:TTIPN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
1ST YEAR; METABOLISM; CAFFEINE; INFANTS; APNEA; PHARMACOKINETICS; ELIMINATION; DISPOSITION; MANAGEMENT; ONTOGENY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lowry, JA Childrens Mercy Hosp, Div Clin Pharmacol & Toxicol, 2401 GillhamRd, Kansas City, MO 64108 USA Childrens Mercy Hosp 2401 Gillham Rd Kansas City MO USA 64108 SA
Citazione:
J.A. Lowry et al., "Theophylline toxicokinetics in premature newborns", ARCH PED AD, 155(8), 2001, pp. 934-939

Abstract

Background: While cytochrome P4501A2 is the primary pathway for theophylline (aminophylline ethylenediamine) metabolism in adults, it is developmentally immature in the newborn. Objective: To report the developmental differences in theophylline toxicokinetics of neonates. Design: Case series. Three premature neonates received inadvertent intravenous overdoses of theophylline for apnea of prematurity while in newborn intensive care. Maximum serum concentrations ranged from 55 to 123 mg/L. Theophylline-derived caffeine levels plateaued at 8.4 to 13 mg/L and did not decline during the sampling period. All newborns experienced sinus tachycardia and agitation. Sequential theophylline and caffeine serum levels were obtained periodically for 62 to 100 hours. In contrast to older children and adults, in whom theophylline disposition follows zero-order kinetics at highconcentrations, a monoexponential function best described theophylline elimination in the premature newborn, with half-lives ranging from 24.7 to 36.5 hours and estimated clearance from 0.02 to 0.05 L/kg per hour. These values are consistent with those previously reported in neonates. All patients were treated with supportive care without invasive procedures. No seizures or apparent sequelae occurred. Conclusion: Developmental differences in the balance between nonrenal (ie,metabolic) and renal elimination pathways produce the unique toxicokinetics of theophylline in the neonate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:58:42