Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cell death in the rat thymus: A minireview
Autore:
Quaglino, D; Ronchetti, IP;
Indirizzi:
Univ Modena & Reggio Emilia, Dept Biomed Sci Gen Pathol, I-41100 Modena, Italy Univ Modena & Reggio Emilia Modena Italy I-41100 , I-41100 Modena, Italy
Titolo Testata:
APOPTOSIS
fascicolo: 5, volume: 6, anno: 2001,
pagine: 389 - 401
SICI:
1360-8185(200110)6:5<389:CDITRT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED THYMOCYTE APOPTOSIS; DNA FRAGMENTATION; IMMUNE-SYSTEM; GENE-EXPRESSION; LYMPH-NODES; IN-VIVO; BCL-X; ENDONUCLEASE ACTIVATION; ELECTROMAGNETIC-FIELDS; REGULATING APOPTOSIS;
Keywords:
cell death; rat; morphology; agents; thymocytes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
130
Recensione:
Indirizzi per estratti:
Indirizzo: Quaglino, D Univ Modena & Reggio Emilia, Dept Biomed Sci Gen Pathol, Via Campi 287, I-41100 Modena, Italy Univ Modena & Reggio Emilia Via Campi 287 Modena Italy I-41100
Citazione:
D. Quaglino e I.P. Ronchetti, "Cell death in the rat thymus: A minireview", APOPTOSIS, 6(5), 2001, pp. 389-401

Abstract

During the last decades, the literature has clearly established the fundamental role of the thymus in the development of an effective immune system. During thymocyte development and maturation, potentially autoreactive thymocytes are eliminated by a process known as apoptosis or programmed cell death responsible for the negative selection occurring within the thymus. Thisprocess is in sharp contrast to other types of cell death referred to as necrosis. Actually, three different types of cell death have been recently observed morphologically in the rat thymus, i.e. necrosis, apoptosis and clustered cell death. Moreover, among the numerous factors influencing thymocyte cell death, particular attention has been paid to hormones, chemicals, biological compounds and physical agents that may influence the type and/or the extent of cell death. Finally, a brief overview has been devoted to thecontribution of mitochondria, nitric oxide, glutathione and intracellular levels of cations in addition to the activity of genes as cdk2, p53, Fas and members' of the Bcl2 family in modulating rat thymus cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:13:17