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Titolo:
Early decrease of survival signal-related proteins in spinal motor neuronsof presymptomatic transgenic mice with a mutant SOD1 gene
Autore:
Warita, H; Manabe, Y; Murakami, T; Shiro, Y; Nagano, I; Abe, K;
Indirizzi:
Okayama Univ, Sch Med, Dept Neurol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Neurol, Okayama 7008558, Japan
Titolo Testata:
APOPTOSIS
fascicolo: 5, volume: 6, anno: 2001,
pagine: 345 - 352
SICI:
1360-8185(200110)6:5<345:EDOSSP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; CU,ZN SUPEROXIDE-DISMUTASE; CEREBELLAR GRANULE NEURONS; NERVE GROWTH-FACTOR; PHOSPHATIDYLINOSITOL 3-KINASE; TYROSINE NITRATION; INDUCED APOPTOSIS; OXIDATIVE DAMAGE; NITRIC-OXIDE; AKT KINASE;
Keywords:
phosphatidylinositol 3-kinase; Akt; SOD1; transgenic mouse; ALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, K Okayama Univ, Sch Med, Dept Neurol, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 008558, Japan
Citazione:
H. Warita et al., "Early decrease of survival signal-related proteins in spinal motor neuronsof presymptomatic transgenic mice with a mutant SOD1 gene", APOPTOSIS, 6(5), 2001, pp. 345-352

Abstract

The mechanisms of motor neuronal death in amyotrophic lateral sclerosis (ALS) remain to be unclear. Phosphatidy-linositol 3-kinase (PI3-K) and its main downstream effector, Akt/protein kinase B (PKB) have been shown to play a central role in neuronal survival against apoptosis supported by neurotrophic factors. In order to investigate a possible impairment of survival signaling, we examined expressions of PI3-K and Akt in the spinal cord of the transgenic mice overexpressing a mutant Cu/Zn superoxide dismutase (SOD1) gene, a valuable model for human ALS. Immunoblotting and immunohistochemicalanalyses showed that the majority of spinal motor neurons lost the immunoreactivities for both PI3-K and Akt in the early and presymptomatic stage that preceded significant loss of the neurons. The present results suggest that an early decrease of survival signal proteins in the spinal motor neurons may account for the subsequent motor neuronal loss in this animal model of ALS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:06:16