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Titolo:
Vascular endothelial cells express a functional fas-receptor due to lack of hemodynamic forces
Autore:
Freyberg, MA; Kaiser, D; Graf, R; Friedl, P;
Indirizzi:
Tech Univ Darmstadt, Inst Biochem, D-64287 Darmstadt, Germany Tech Univ Darmstadt Darmstadt Germany D-64287 D-64287 Darmstadt, Germany
Titolo Testata:
APOPTOSIS
fascicolo: 5, volume: 6, anno: 2001,
pagine: 339 - 343
SICI:
1360-8185(200110)6:5<339:VECEAF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID SHEAR-STRESS; APOPTOSIS; SIGNAL; FLOW; INDUCTION; SURFACE; DEATH;
Keywords:
apoptosis; arteriosclerosis; endothelium; fas-receptor; mechanical; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Friedl, P Tech Univ Darmstadt, Inst Biochem, Petersenstr 22, D-64287 Darmstadt, Germany Tech Univ Darmstadt Petersenstr 22 Darmstadt Germany D-64287ny
Citazione:
M.A. Freyberg et al., "Vascular endothelial cells express a functional fas-receptor due to lack of hemodynamic forces", APOPTOSIS, 6(5), 2001, pp. 339-343

Abstract

The fas system is present in atherosclerotic lesions. However, its role inthe initiation and progression is still unclear. Here we show that in endothelial cells (EC) the expression of the fas receptor is regulated by flow conditions. The EC of the vascular system are regularly exposed to a range of hemodynamic forces with great impact on cellular structures and functions. Recently it was reported that in endothelial cells the lack of hemodynamic forces as well as irregular flow conditions trigger apoptosis by induction of a mechanosensitive autocrine loop of thrombospondin-1 and the alpha (V)beta (3) integrin/integrin-associated protein complex. Here we show that EC cultivated under regular laminar flow conditions are devoid of the fas-receptor whereas cultivation under static conditions as well as under turbulence leads to its expression. Stimulation of the fas-receptor by its ligandincreases the amount of apoptotic cells by twofold; the increase can be prevented by blocking the fas-receptor. The availability of the expressed fasreceptor for stimulation by its ligand hints at a role as a tool for progression of atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:07:01