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Titolo:
Specific glycosylation of alpha(1)-acid glycoprotein characterises patients with familial Mediterranean fever and obligatory carriers of MEFV
Autore:
Poland, DCW; Drenth, JPH; Rabinovitz, E; Livneh, A; Bijzet, J; Hof, BV; van Dijk, W;
Indirizzi:
Vrije Univ Amsterdam, Fac Med, Inst Immunol & Inflammatory Dis, Dept Med Chem, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 BT erdam, Netherlands Univ Med Ctr St Radboud, Dept Med, Div Gastroenterol, Nijmegen, Netherlands Univ Med Ctr St Radboud Nijmegen Netherlands rol, Nijmegen, Netherlands Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Univ Groningen Hosp, Dept Med, Div Rheumatol, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands matol, Groningen, Netherlands
Titolo Testata:
ANNALS OF THE RHEUMATIC DISEASES
fascicolo: 8, volume: 60, anno: 2001,
pagine: 777 - 780
SICI:
0003-4967(200108)60:8<777:SGOAGC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATION-INDUCED EXPRESSION; ACUTE-PHASE PROTEINS; ALPHA-1-ACID GLYCOPROTEIN; HYPERIMMUNOGLOBULINEMIA-D; RHEUMATOID-ARTHRITIS; AFFINITY-CHROMATOGRAPHY; CLINICAL SPECTRUM; CONCANAVALIN-A; SERUM; MICROHETEROGENEITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: van Dijk, W Vrije Univ Amsterdam, Fac Med, Inst Immunol & Inflammatory Dis, Dept Med Chem, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
D.C.W. Poland et al., "Specific glycosylation of alpha(1)-acid glycoprotein characterises patients with familial Mediterranean fever and obligatory carriers of MEFV", ANN RHEUM D, 60(8), 2001, pp. 777-780

Abstract

Background-Familial Mediterranean fever (FMF) is a periodic febrile disorder, characterised by fever and serositis. The acute phase response during attacks of FMF results from the release of cytokines, which in turn induce increased expression and changed glycosylation of acute phase proteins. A recent study indicated that attacks in FMF are accompanied by a rise of plasma concentrations of serum amyloid A (SAA) and C reactive. protein (CRP), which remain significantly raised during remission relative to healthy controls. Another study suggested that obligatory heterozygotes also display an inflammatory acute phase response. Objective-To determine the state of inflammation in homozygotic and heterozygotic MEFV genotypes. Methods-CRP and SAA were studied by enzyme linked immunosorbent assay (ELISA). The glycosylation of the acute phase protein, alpha (1)-acid glycoprotein (AGP), was visualised with crossed affinoimmuno-electrophoresis with concanavalin A as diantennary glycan-specific component and Aleuria aurantia lectin as fucose-specific affinity component. Results-FMF attacks were associated with an increase (p<0.05) in the seruminflammation parameters CRP, SAA, and AGP. The glycosylation of AGP showedan increase (p<0.05) in fucosylated AGP glycoforms, whereas the branching of the glycans remained unaffected. The glycosylation of AGP in the MEFV carrier group, compared with that in a healthy control group, was characterised by a significant increase (p<0.05) in branching of the glycans, whereas the fucosylation remained unaffected. Conclusion-The findings suggest an FMF-specific release of cytokines, resulting in a different glycosylation of AGP between a homozygotic and heterozygotic MEFV genotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:10:13