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Titolo:
Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease
Autore:
Nakamura, T; Dhawan, V; Chaly, T; Fukuda, M; Ma, YL; Breeze, R; Greene, P; Fahn, S; Freed, C; Eidelberg, D;
Indirizzi:
N Shore Long Isl Jewish Res Inst, Funct Brain Imaging Lab, Manhasset, NY 11030 USA N Shore Long Isl Jewish Res Inst Manhasset NY USA 11030 set, NY 11030 USA NYU, Sch Med, Dept Neurol, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Neurol, New York, NY USA Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Univ Colorado, Hlth Sci Ctr, Dept Neurosurg, Denver, CO 80202 USA Univ Colorado Denver CO USA 80202 r, Dept Neurosurg, Denver, CO 80202 USA Univ Colorado, Hlth Sci Ctr, Ctr Neurosci, Denver, CO 80202 USA Univ Colorado Denver CO USA 80202 Ctr, Ctr Neurosci, Denver, CO 80202 USA Univ Colorado, Hlth Sci Ctr, Div Clin Pharmacol & Toxicol, Denver, CO 80202 USA Univ Colorado Denver CO USA 80202 armacol & Toxicol, Denver, CO 80202 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 2, volume: 50, anno: 2001,
pagine: 181 - 187
SICI:
0364-5134(200108)50:2<181:BPETSO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PARKINSONISM; F-18 FLUORODOPA; PET; TRANSPLANTATION; SURVIVAL; GRAFTS; TERM; PATIENT; TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Eidelberg, D N Shore Long Isl Jewish Res Inst, Funct Brain Imaging Lab, 350 Community Dr, Manhasset, NY 11030 USA N Shore Long Isl Jewish Res Inst 350 Community Dr Manhasset NY USA 11030
Citazione:
T. Nakamura et al., "Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease", ANN NEUROL, 50(2), 2001, pp. 181-187

Abstract

We assessed nigrostriatal dopaminergic function in Parkinson's disease (PD) patients undergoing a double-blind, placebo-controlled surgical trial of embryonic dopamine cell implantation. Forty PD patients underwent positron emission tomography (PET) imaging with [F-18]fluorodopa (FDOPA) prior to randomization to transplantation or placebo surgery. The 39 surviving patients were rescanned one year following surgery. Images were quantified by investigators blinded to treatment status and clinical outcome. Following unblinding, we determined the effects of treatment status and age on the interval changes in FDOPA/PET signal. Blinded observers detected a significant increase in FDOPA uptake in the putamen of the group receiving implants compared to the placebo surgery patients (40.3%). Increases in putamen FDOPA uptake were similar in both younger (age less than or equal to 60 years) and older (age >60 years) transplant recipients. Significant decrements in putamen uptake were evident in younger placebo-operated patients (-6.5%) but not in their older counterparts. Correlations between the PET changes and clinical outcome were significant only in the younger patient subgroup (r = 0.58). The findings suggest that patient age does not influence graft viabilityor development in the first postoperative year. However, host age may influence the time course of the downstream functional changes that are needed for clinical benefit to occur.

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Documento generato il 20/06/19 alle ore 17:11:32