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Titolo:
Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease
Autore:
Itoh, N; Arai, H; Urakami, K; Ishiguro, K; Ohno, H; Hampel, H; Buerger, K; Wiltfang, J; Otto, M; Kretzschmar, H; Moeller, HJ; Imagawa, M; Kohno, H; Nakashima, K; Kuzuhara, S; Sasaki, H; Imahori, K;
Indirizzi:
Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ed, Sendai, Miyagi 9808574, Japan Mie Univ, Sch Med, Dept Neurol, Tsu, Mie 514, Japan Mie Univ Tsu Mie Japan 514 niv, Sch Med, Dept Neurol, Tsu, Mie 514, Japan Tottori Univ, Fac Med, Inst Neurol Sci, Div Neurol, Yonago, Tottori 683, Japan Tottori Univ Yonago Tottori Japan 683 Neurol, Yonago, Tottori 683, Japan Mitsubishi Kasei Inst Life Sci, Machida, Tokyo, Japan Mitsubishi Kasei Inst Life Sci Machida Tokyo Japan Machida, Tokyo, Japan Mitsubishi Chem Corp, Diagnost Syst Dept, Tokyo, Japan Mitsubishi Chem Corp Tokyo Japan Corp, Diagnost Syst Dept, Tokyo, Japan Amagasaki Hosp, Dept Psychiat, Amagasaki, Hyogo, Japan Amagasaki Hosp Amagasaki Hyogo Japan t Psychiat, Amagasaki, Hyogo, Japan Univ Munich, Dept Psychiat, Dementia Res Sect, Munich, Germany Univ Munich Munich Germany Psychiat, Dementia Res Sect, Munich, Germany Univ Gottingen, Dept Psychiat, Gottingen, Germany Univ Gottingen Gottingen Germany gen, Dept Psychiat, Gottingen, Germany Univ Gottingen, Dept Neurol, Gottingen, Germany Univ Gottingen GottingenGermany ingen, Dept Neurol, Gottingen, Germany Univ Munich, Inst Neuropathol, D-8000 Munich, Germany Univ Munich MunichGermany D-8000 st Neuropathol, D-8000 Munich, Germany
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 2, volume: 50, anno: 2001,
pagine: 150 - 156
SICI:
0364-5134(200108)50:2<150:LMSOCF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; CREUTZFELDT-JAKOB-DISEASE; CORTICOBASAL DEGENERATION; INTERNATIONAL WORKSHOP; VASCULAR DEMENTIA; CRITERIA; MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, H Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ai, Miyagi 9808574, Japan
Citazione:
N. Itoh et al., "Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease", ANN NEUROL, 50(2), 2001, pp. 150-156

Abstract

We surveyed a total of 570 cerebrospinal fluid (CSF) samples from a variety of diseases, including Alzheimer's disease (AD; n = 236), non-AD-dementedand nondemented diseases (n = 239), and normal controls (n. = 95) to quantitate levels of tau protein phosphorylated at serine 199 (CSF/phospho-tau(199)) by a recently established sandwich ELISA. The CSF/phospho-tau(199) levels in the AD group were significantly elevated compared to those in all the other non-AD groups. Receiver operating characteristics curves showed that the diagnostic sensitivity and specificity for the AD group vs all the other non-AD groups using the CSF/phospho-tau(199) were 85.2% and 85.0%, respectively. Furthermore, there was a significant positive correlation betweenCSF/phospho-tau(199) and CSF/total-tau levels in the AD group. Elevated CSF/phospho-tau(199) in the AD group was noted irrespective of age, gender, dementia severity, and number of apolipoprotein E4 alleles. Thus, we suggestthat CSF/phospho-tan(199) may be a novel and logical biomarker in supporting antemortem diagnosis of AD.

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Documento generato il 22/01/20 alle ore 07:17:10