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Titolo:
Efficacy of cidofovir in an HIV infected patient with an acyclovir and foscarnet resistant herpes simplex virus infection
Autore:
Saint-Leger, E; Fillet, AM; Malvy, D; Rabanel, B; Caumes, E;
Indirizzi:
Grp Hosp Pitie Salpetriere, Serv Virol CERVI, F-75561 Paris 13, France GrpHosp Pitie Salpetriere Paris France 13 RVI, F-75561 Paris 13, France Hop St Andre, Serv Med Interne & Malad Trop, Bordeaux, France Hop St Andre Bordeaux France Med Interne & Malad Trop, Bordeaux, France Grp Hosp Pitie Salpetriere, Serv Malad Infect & Trop, F-75634 Paris, France Grp Hosp Pitie Salpetriere Paris France F-75634 p, F-75634 Paris, France
Titolo Testata:
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
fascicolo: 6-7, volume: 128, anno: 2001,
pagine: 747 - 749
SICI:
0151-9638(200106/07)128:6-7<747:EOCIAH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
FRE
Soggetto:
AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Saint-Leger, E Grp Hosp Pitie Salpetriere, Serv Virol CERVI, 83 Blvd Hop, F-75561 Paris 13, France Grp Hosp Pitie Salpetriere 83 Blvd Hop Paris France 13 nce
Citazione:
E. Saint-Leger et al., "Efficacy of cidofovir in an HIV infected patient with an acyclovir and foscarnet resistant herpes simplex virus infection", ANN DER VEN, 128(6-7), 2001, pp. 747-749

Abstract

Background. We report the case of an AIDS patient, whose persistant HSV2 ulceration was clinically and phenotypicaly resistant to acyclovir and foscarnet. Only five clinical isolates of simultaneous acyclovir and foscarnet resistance have been previously described. Case report. This patient, without history of opportunistic infection, washospitalized for a recurrent scrotal ulceration resistant to several antiviral treatment such as acyclovir, valacyclovir or foscarnet. The CD4 count was stable at 150/mm(3) and the HIV viral load was below detection level. The last recurrence appeared rapidly under valacyclovir therapy which had been introduced after 65 days of foscarnet therapy. Thus, the patient received a new dose of foscarnet. After initial efficacy, the ulceration increasedonce again. HSV2 phenotypic determination was done and detected, at that time, a double resistance to acyclovir and foscarnet. Healing was obtained with intravenous cidofovir. Discussion. Foscarnet and acyclovir resistance in an HSV2 isolate is rare. This report presents several particularities. First, whereas the earlier published patients with an acyclovir and foscarnet resistant strain were widely immunocompromised, this was not the Case for our patient. Secondly, in contrast with most precedent observations in which acyclovir-resistant strain disappeared after foscarnet therapy, in our case the acyclovir resistantstrain remained after foscarnet therapy. Finally, few reports concerned the clinical efficacy of cidofovir in HSV infection. In this case, we proved that intravenously cidofovir was highly and rapidly effective on acyclovir and foscarnet resistant strains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:27:36