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Titolo:
Oral tolerance induction by type V collagen downregulates lung allograft rejection
Autore:
Yasufuku, K; Heidler, KM; ODonnell, PW; Smith, GN; Cummings, OW; Foresman, BH; Fujisawa, T; Wilkes, DS;
Indirizzi:
Indiana Univ, Sch Med, Div Pulm & Crit Care Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pathol, Dept Microbiol, Indianapolis, IN 46202USA Indiana Univ Indianapolis IN USA 46202 crobiol, Indianapolis, IN 46202USA Indiana Univ, Sch Med, Dept Pathol, Dept Immunol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 mmunol, Indianapolis, IN 46202 USA Chiba Univ, Sch Med, Inst Pulm Canc Res, Dept Surg, Chiba, Japan Chiba Univ Chiba Japan Med, Inst Pulm Canc Res, Dept Surg, Chiba, Japan
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 26 - 34
SICI:
1044-1549(200107)25:1<26:OTIBTV>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; RAT CARDIAC ALLOGRAFTS; TRANSPLANTATION; MODEL; ALLOANTIGEN; MECHANISMS; PEPTIDES; LOCALIZATION; SUPPRESSION; PATHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wilkes, DS Indiana Univ, Sch Med, Div Pulm & Crit Care Med, Dept Med, 1001W Tenth StOPW 425, Indianapolis, IN 46202 USA Indiana Univ 1001 W Tenth StOPW 425 Indianapolis IN USA 46202
Citazione:
K. Yasufuku et al., "Oral tolerance induction by type V collagen downregulates lung allograft rejection", AM J RESP C, 25(1), 2001, pp. 26-34

Abstract

Immunization with specific proteins or peptides has been used to induce immunologic tolerance to allografts other than the lung. Recently, we have reported that the immune response to lung alloantigen also involves an immuneresponse to type V collagen [col(V)]. The purpose of the current study wasto determine if oral administration of col(V) to lung allograft recipientsbefore transplantation downregulates acute rejection episodes. The data show that, compared with controls, col(V)-fed recipients had fewer polymorphonuclear cells and lymphocytes in allograft bronchoalveolar lavage fluid, and reduced rejection pathology. Data showing that col(V)fed allograft recipients had diminished delayed-type hypersensitivity (DTH) responses to donor alloantigens suggest that feeding col(V) prevented allograft rejection by inducing tolerance to donor antigens. Systemic production of transforming growth factor (TGF)-beta interleukin (IL)-4, or IL-10 has been reported to bea mechanism for oral tolerance-induced suppression of immune responses. Feeding col(V) induced upregulated production of TGF-beta but not IL-4 or IL-10 in serum. Neutralizing TGF-beta recovered the DTH response to donor antigen in tolerant allograft recipients. Collectively, these data show that oral administration of col(V) is a novel approach to induce immunologic tolerance to lung allografts, and that TGF-beta contributed to suppression of the rejection response.

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Documento generato il 21/09/20 alle ore 12:49:28