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Titolo:
Comparative T-cell responses during pregnancy in large animals and humans
Autore:
Meeusen, ENT; Bischof, RJ; Lee, CS;
Indirizzi:
Univ Melbourne, Sch Vet Sci, Ctr Anim Biotechnol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 2, volume: 46, anno: 2001,
pagine: 169 - 179
SICI:
1046-7408(200108)46:2<169:CTRDPI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE REPRODUCTIVE-TRACT; QUANTITATIVE-ANALYSIS; HUMAN DECIDUA; SYNEPITHELIOCHORIAL PLACENTA; INTRAEPITHELIAL LYMPHOCYTES; TROPHOBLAST CELLS; HUMAN ENDOMETRIUM; PIG UTERUS; SHEEP; EXPRESSION;
Keywords:
cow; deer; horse; pig; placentation; sheep; alpha beta T cells; gamma delta T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Meeusen, ENT Univ Melbourne, Sch Vet Sci, Ctr Anim Biotechnol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 3010, Australia
Citazione:
E.N.T. Meeusen et al., "Comparative T-cell responses during pregnancy in large animals and humans", AM J REPROD, 46(2), 2001, pp. 169-179

Abstract

PROBLEM: Placentation in different large animal species shows a remarkablediversity in the level of trophoblast invasion into the maternal endometrial tissues. We wish to determine the influence of implantation on T-cell responses during pregnancy. METHOD OF STUDY: Review of the literature and current data. RESULTS: alphabeta -TCR (+) T cells are only prominent during early pregnancy in specieswith relatively non-invasive placentation (pig and horse) but are rapidly downregulated in species with more invasive placentae. gamma delta -TCR (+)T cells are prominent in species with moderate trophoblast invasion (ruminants) where they increase dramatically during mid and late pregnancy. gammadelta -TCR (+) T cells remain prominent during late gestation in species with highly invasive placentation (humans) and, in addition, a distinct gamma delta T-cell population is present in first trimester decidua where it may play a regulatory role in controlling natural killer cell activity. The gamma delta -TCR (+) population present in both ruminants and humans shows large granular morphology and contains antimicrobial proteins, suggesting their function may be to protect the uterine environment from infection during pregnancy and parturition. CONCLUSION: The comparative analysis of T-cell responses during pregnancy in different large animal species supports an increasing role for cells of the innate immune response (NK and gamma delta T cells) and a downregulation of the adaptive immune response with increasingly invasive placentation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:41:10