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Titolo:
Hippocampal and anterior cingulate activation deficits in patients with geriatric depression
Autore:
de Asis, JM; Stern, E; Alexopoulos, GS; Pan, H; Van Gorp, W; Blumberg, H; Kalayam, B; Eidelberg, D; Kiosses, D; Silbersweig, DA;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, New York, NY 10021 USA Cornell Univ New York NY USA 10021 uroimaging Lab, New York, NY 10021 USA N Shore Univ Hosp, Dept Neurol, Manhasset, NY USA N Shore Univ Hosp Manhasset NY USA Hosp, Dept Neurol, Manhasset, NY USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 8, volume: 158, anno: 2001,
pagine: 1321 - 1323
SICI:
0002-953X(200108)158:8<1321:HAACAD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; UNIPOLAR DEPRESSION; MAJOR DEPRESSION; MOOD DISORDERS; LATE-LIFE; ABNORMALITIES; DYSFUNCTION; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Silbersweig, DA Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, Box 140,525 E 68th St, New York, NY 10021 USA Cornell Univ Box 140,525 E 68th St New York NY USA 10021 A
Citazione:
J.M. de Asis et al., "Hippocampal and anterior cingulate activation deficits in patients with geriatric depression", AM J PSYCHI, 158(8), 2001, pp. 1321-1323

Abstract

Objective: The authors assessed frontotemporal function in patients with geriatric depression, a debilitating and increasingly prevalent disorder that has not been examined with brain activation paradigms. Method: Six depressed elderly patients and five healthy comparison subjects underwent high-sensitivity [O-15]H2O positron emission tomography scans during a paced word generation task and a resting condition. Results: Bilateral activation deficits were noted in the dorsal anterior cingulate gyrus and hippocampus of the depressed geriatric patients relativeto the comparison subjects. Patients had memory deficits that correlated with lower hippocampal activity during both rest and activation. Conclusions: These initial findings suggest that hippocampal and dorsal anterior cingulate hypoactivation may constitute contributing neural substrates of geriatric depression. They also suggest that hippocampal dysfunction is related to the memory dysfunction characteristic of this disorder.

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Documento generato il 25/01/20 alle ore 09:33:52