Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Superior temporal gyrus abnormalities in early-onset schizophrenia: Similarities and differences with adult-onset schizophrenia
Autore:
Matsumoto, H; Simmons, A; Williams, S; Hadjulis, M; Pipe, R; Murray, R; Frangou, S;
Indirizzi:
Inst Psychiat, Sect Neurobiol Psychosis, Div Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 8, volume: 158, anno: 2001,
pagine: 1299 - 1304
SICI:
0002-953X(200108)158:8<1299:STGAIE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE D2 RECEPTORS; AUDITORY HALLUCINATIONS; THOUGHT-DISORDER; ANTIPSYCHOTIC-DRUGS; I-125 EPIDEPRIDE; LOBE STRUCTURES; VOLUMETRIC MRI; BASAL GANGLIA; HUMAN BRAIN; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Frangou, S Inst Psychiat, Sect Neurobiol Psychosis, Div Psychol Med, De Crespigny Pk,London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF , England
Citazione:
H. Matsumoto et al., "Superior temporal gyrus abnormalities in early-onset schizophrenia: Similarities and differences with adult-onset schizophrenia", AM J PSYCHI, 158(8), 2001, pp. 1299-1304

Abstract

Objective: The superior temporal gyrus is associated with developmental mechanisms of brain lateralization and the pathogenesis of language-related schizophrenic symptoms. it therefore lends itself to investigation of developmental deviance in the early onset of schizophrenia. Method. Using stereological methods, the authors obtained bilateral measurements of the superior temporal gyrus (total, gray matter, and white mattervolumes) from 40 adolescents with recent-onset schizophrenia and an equal number of matched healthy volunteers Symptoms were rated by using the Positive and Negative Syndrome Scale. Results: The total and gray matter volume of the right superior temporal gyrus was significantly lower in patients with early-onset schizophrenia than in the healthy volunteers, even after differences in whole brain volume were controlled. Bilateral superior temporal gyrus volumes were positively correlated with the age at onset of psychosis, while severity of thought disorder and hallucinations were inversely related to right superior temporal gyrus volume. Conclusions. In patients with early-onset schizophrenia, the predominantlyright-sided volumetric abnormalities found in the superior temporal gyrus may reflect a particularly early neurodevelopmental disruption, The relationship between language-related symptoms and superior temporal gyrus volume is similar to that seen in adult-onset cases but not as lateralized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 12:27:54