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Titolo:
CSF norepinephrine concentrations in posttraumatic stress disorder
Autore:
Geracioti, TD; Baker, DG; Ekhator, NN; West, SA; Hill, KK; Bruce, AB; Schmidt, D; Rounds-Kugler, B; Yehuda, R; Keck, PE; Kasckow, JW;
Indirizzi:
Vet Affairs Med Ctr, Mental Hlth Serv, Cincinnati, OH 45220 USA Vet Affairs Med Ctr Cincinnati OH USA 45220 erv, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45221 USA Univ Cincinnati Cincinnati OH USA 45221 sychiat, Cincinnati, OH 45221 USA Vanderbilt Univ, Med Ctr, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA d Ctr, Dept Psychiat, Nashville, TN USA Mt Sinai Sch Med, Bronx, NY USA Mt Sinai Sch Med Bronx NY USAMt Sinai Sch Med, Bronx, NY USA Vet Affairs Med Ctr, Bronx, NY USA Vet Affairs Med Ctr Bronx NY USAVet Affairs Med Ctr, Bronx, NY USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 8, volume: 158, anno: 2001,
pagine: 1227 - 1230
SICI:
0002-953X(200108)158:8<1227:CNCIPS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; CEREBROSPINAL-FLUID NOREPINEPHRINE; VIETNAM COMBAT VETERANS; PLASMA NOREPINEPHRINE; CATECHOLAMINE EXCRETION; URINARY NOREPINEPHRINE; PTSD; NEUROENDOCRINE; METABOLITES; DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Geracioti, TD Vet Affairs Med Ctr, Mental Hlth Serv, Box 116A,3200 Vine St, Cincinnati, OH 45220 USA Vet Affairs Med Ctr Box 116A,3200 Vine St Cincinnati OH USA 45220
Citazione:
T.D. Geracioti et al., "CSF norepinephrine concentrations in posttraumatic stress disorder", AM J PSYCHI, 158(8), 2001, pp. 1227-1230

Abstract

Objective. Despite evidence of hyperresponsive peripheral and central nervous system (CNS) noradrenergic activity in posttraumatic stress disorder (PTSD), direct measures of CNS norepinephrine in PTSD have been lacking. The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD. Method: CSF samples were obtained serially over a 6-hour period in 11 malecombat veterans with chronic PTSD and eight healthy men through an indwelling subarachnoid catheter. Thus the authors were able to determine hourly CSF norepinephrine concentrations under baseline (unstressed) conditions. Severity of the patients' PTSD symptoms was assessed with the Clinician-Administered PTSD Scale. Results. CSF norepinephrine concentrations were significantly higher in the men with PTSD than in the healthy men. Moreover, CSF norepinephrine levels strongly and positively correlated with the severity of PTSD symptoms, Plasma norepinephrine concentrations showed no significant relationship with the severity of PTSD symptoms. Conclusions: These findings reveal the presence of greater CNS noradrenergic activity under baseline conditions in patients with chronic PTSD than inhealthy subjects and directly link this pathophysiologic observation with the severity of the clinical posttraumatic stress syndrome.

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Documento generato il 10/04/20 alle ore 01:40:37