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Titolo:
Substance use disorders in patients with posttraumatic stress disorder: A review of the literature
Autore:
Jacobsen, LK; Southwick, SM; Kosten, TR;
Indirizzi:
Yale Univ, VA Connecticut Healthcare Syst, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 cut Healthcare Syst, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Med, Dept Psychiat, W Haven, CT 06516 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 8, volume: 158, anno: 2001,
pagine: 1184 - 1190
SICI:
0002-953X(200108)158:8<1184:SUDIPW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; INDUCED BEHAVIORAL SENSITIZATION; PARAVENTRICULAR NUCLEUS; COMBAT VETERANS; FACTOR CRF; ALCOHOL-WITHDRAWAL; COCAINE DEPENDENCE; ETHANOL WITHDRAWAL; RESTRAINT STRESS; INDUCED RELAPSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Jacobsen, LK Yale Univ, VA Connecticut Healthcare Syst, W Haven Campus,950Campbell Ave, W Haven, CT 06516 USA Yale Univ W Haven Campus,950 Campbell Ave W Haven CT USA 06516
Citazione:
L.K. Jacobsen et al., "Substance use disorders in patients with posttraumatic stress disorder: A review of the literature", AM J PSYCHI, 158(8), 2001, pp. 1184-1190

Abstract

Objective: Alcohol use disorders and other substance use disorders are extremely common among patients with posttraumatic stress disorder (PTSD). This article reviews studies pertaining to the epidemiology, clinical phenomenology, and pathophysiology of comorbid PTSD and substance use disorders. Method: Studies were identified by means of computerized and manual searches. The review of research on the pathophysiology of PTSD and substance usedisorders was focused on studies of the hypothalamic-pituitary-adrenal axis and the noradrenergic system. Results: High rates of comorbidity suggest that PTSD and substance use disorders are functionally related to one another. Most published data supporta pathway whereby PTSD precedes substance abuse or dependence. Substances are initially used to modify PTSD symptoms. With the development of dependence, physiologic arousal resulting from substance withdrawal may exacerbatePTSD symptoms, thereby contributing to a relapse of substance use. Preclinical work has led to the proposal that in PTSD, corticotropin-releasing hormone and noradrenergic systems may interact such that the stress response is progressively augmented. Patients may use sedatives, hypnotics, or alcohol in an effort to interrupt this progressive augmentation. Conclusions: Vigorous control of withdrawal and PTSD-related arousal symptoms should be sought during detoxification of patients with comorbid PTSD and substance use disorders. Inclusion of patients with comorbid PTSD and substance use disorders in neurobiologic research and in clinical trials willbe critical for development of effective treatments for this severely symptomatic patient population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:42:43