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Titolo:
No association between a promoter dopamine D-4 receptor gene variant and schizophrenia
Autore:
Jonsson, EG; Ivo, R; Forslund, K; Mattila-Evenden, M; Rylander, G; Cichon, S; Propping, P; Nothen, MM; Asberg, M; Sedvall, GC;
Indirizzi:
Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 ci, SE-17176 Stockholm, Sweden Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany Univ Bonn Bonn GermanyD-5300 nn, Inst Human Genet, D-5300 Bonn, Germany Univ Antwerp, Dept Med Genet, Wilrijk, Belgium Univ Antwerp Wilrijk Belgium Antwerp, Dept Med Genet, Wilrijk, Belgium
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 6, volume: 105, anno: 2001,
pagine: 525 - 528
SICI:
0148-7299(20010808)105:6<525:NABAPD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLELIC VARIATION; CLOZAPINE; POLYMORPHISMS; DRD4; LINKAGE; MUTATION;
Keywords:
DRD4; schizophrenia; association study; promoter polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Jonsson, EG Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 Stockholm, Sweden
Citazione:
E.G. Jonsson et al., "No association between a promoter dopamine D-4 receptor gene variant and schizophrenia", AM J MED G, 105(6), 2001, pp. 525-528

Abstract

The dopamine D-4 receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (-521C/T) in the dopamine D-4 receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132) and control subjects (n = 388) were analyzed with respect to the DRD4 -521C/T polymorphism. No significant case control differences emerged. The present results do not support a major role for DRD4 in the etiology of schizophrenia among Caucasians from Sweden. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 20/01/20 alle ore 16:14:42