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Titolo:
Cystatin C is not more sensitive than creatinine for detecting early renalimpairment in patients with diabetes
Autore:
Oddoze, C; Morange, S; Portugal, H; Berland, Y; Dussol, B;
Indirizzi:
Hop Conception, Serv Nephrol, F-13385 Marseille 05, France Hop ConceptionMarseille France 05 Nephrol, F-13385 Marseille 05, France Hop St Marguerite, Cent Lab, Marseille, France Hop St Marguerite Marseille France guerite, Cent Lab, Marseille, France Hop St Marguerite, Ctr Invest Clin, Marseille, France Hop St Marguerite Marseille France , Ctr Invest Clin, Marseille, France
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 2, volume: 38, anno: 2001,
pagine: 310 - 316
SICI:
0272-6386(200108)38:2<310:CCINMS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; INULIN-CLEARANCE; SERUM CREATININE; MARKER; PREDICTION;
Keywords:
cystatin C; beta(2)-microglobulin; creatinine; glomerular filtration rate (GFR); diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Dussol, B Hop Conception, Serv Nephrol & Hemodialyse, 147 Bd Baille, F-13385 Marseille 05, France Hop Conception 147 Bd Baille Marseille France 05 lle 05, France
Citazione:
C. Oddoze et al., "Cystatin C is not more sensitive than creatinine for detecting early renalimpairment in patients with diabetes", AM J KIDNEY, 38(2), 2001, pp. 310-316

Abstract

This study evaluated serum cystatin C as a potential new marker of glomerular filtration rate (GFR) in 49 patients who had steady-state diabetes withearly renal impairment. We determined the correlation between GFR measuredby chromium 51-labeled EDTA and levels of serum cystatin C, serum creatinine, serum beta (2)-microglobulin, endogenous creatinine clearance, and Cockcroft formula. Sensitivity and specificity for the diagnosis of renal failure, defined as a GFR less than either 80 or 60 mL/min/1.73 m(2), were calculated by receiver operating characteristic (ROC) curves for creatinine, cystatin C, and beta (2)-microglobulin. Finally, we compared mean values of these three serum parameters in patients grouped according to GFR using the two definitions of renal failure. Correlation coefficients with GFR were -0.77 for serum creatinine level, -0.65 for serum cystatin C level, -0.71 for serum beta (2)-microglobulin level, +0.56 for endogenous creatinine clearance, and +0.69 for Cockcroft formula (all P < 0.001). With a cutoff value of60 mL/min/1.73 m(2), areas under the ROC curve were 0.972 for beta(2)-microglobulin, 0.925 for cystatin C, and 0.916 for creatinine levels. With a cutoff value of 80 mL/min/1.73 m(2), these were 0.838 for beta (2)-microglobulin, 0.780 for cystatin C, and 0.905 for creatinine levels (P = not significant between parameters). These results were not altered after the exclusion of patients (n = 8) with a serum creatinine level greater than 1.41 mg/dL. When patients were classified into three groups according to GFR (group 1, >80 mL/min/1.73 m(2); group 2,60 to 80 mL/min/1.73 m(2); group 3, <60 mL/min/1.73 m(2)), mean values of serum parameters in the three groups were statistically different (P < 0.0001) except between groups 1 and 2 for cystatin C and beta (2)-microglobulin. With patients classified into two groups (GFR > or < 80 mL/min/1.73 m(2)), mean values for each parameter were statistically different (P < 0.001). Sensitivity, specificity, and positive and negative predictive values for serum creatinine and serum cystatin C levels were very close for both definitions of renal failure. Serum cystatin C Is not better than serum creatinine or serum beta (2)-microglobulin levels forestimating GFR in patients with steady-state diabetes using ROC curves or other validation tests. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:32:21