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Titolo:
Presentation and revascularization outcomes in patients with radiation-induced renal artery stenosis
Autore:
Fakhouri, F; Alanore, AL; Rerolle, JP; Guery, B; Raynaud, A; Plouin, PF;
Indirizzi:
Hop Europeen Georges Pompidou, Dept Hypertens, F-75908 Paris 15, France Hop Europeen Georges Pompidou Paris France 15 , F-75908 Paris 15, France Hop Europeen Georges Pompidou, Dept Cardiovasc Radiol, F-75908 Paris, France Hop Europeen Georges Pompidou Paris France F-75908 F-75908 Paris, France
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 2, volume: 38, anno: 2001,
pagine: 302 - 309
SICI:
0272-6386(200108)38:2<302:PAROIP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCCLUSIVE DISEASE; ANGIOPLASTY; HYPERTENSION; IRRADIATION; THERAPY; HEAD;
Keywords:
radiation; renal artery stenosis; hypertension; radiation nephritis; transluminal angioplasty;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Plouin, PF Hop Europeen Georges Pompidou, Dept Hypertens, 20 Rue Leblanc, F-75908 Paris 15, France Hop Europeen Georges Pompidou 20 Rue Leblanc Paris France 15 e
Citazione:
F. Fakhouri et al., "Presentation and revascularization outcomes in patients with radiation-induced renal artery stenosis", AM J KIDNEY, 38(2), 2001, pp. 302-309

Abstract

This study analyzed the initial presentation and revascularization outcomes of patients with radiation-induced renal artery stenosis, a rare complication of therapeutic irradiation. Of 11 patients with renal artery stenosis after irradiation, 7 patients fulfilled the following criteria: normotension before irradiation, radiation dose greater than 25 grays delivered to therenal arteries, associated perirenal radiation-induced lesions, and absence of arterial disease outside the radiation field. The median age at irradiation was 30 years, and the median local irradiation dose was 40 grays. Themedian time from irradiation to referral was 13 years. All patients were hypertensive at referral, with a median blood pressure (BP) of 171/102 mm Hgand median treatment score of two. The median glomerular filtration rate was 67 mL/min. Two patients had bilateral stenoses and 1 patient had stenosis affecting a single kidney. Stenoses were proximal in 6 patients and truncal in 1 patient, and all had the appearance of atherosclerotic stenosis. Percutaneous transluminal renal artery angioplasty (PTRA) was successful in 5patients, but required multiple insufflations. PTRA failed in 1 patient, who subsequently underwent an aortorenal bypass. After a median follow-up of36 months, 2 patients had died of noncardiovascular causes and 4 patients remained hypertensive, with a median BP of 136/85 mm Hg and median treatment score of two. No restenosis occurred, but aneurysms developed at the siteof angioplasty in 1 patient. If hypertension occurs even decades after irradiation, a radiation-induced renal artery stenosis should be sought in patients who have undergone abdominal irradiation. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:33:46