Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HER2 protein expression and gene amplification in androgen-independent prostate cancer
Autore:
Reese, DM; Small, EJ; Magrane, G; Waldman, FM; Chew, K; Sudilovsky, D;
Indirizzi:
Univ Calif San Francisco, Ctr Comprehens Canc, Urol Oncol Program, Div Hematol Oncol, San Francisco, CA 94115 USA Univ Calif San Francisco San Francisco CA USA 94115 ancisco, CA 94115 USA Univ Calif San Francisco, Ctr Comprehens Canc, Dept Lab Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Ctr Comprehens Canc, Dept Pathol, San Francisco,CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco,CA 94143 USA
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 2, volume: 116, anno: 2001,
pagine: 234 - 239
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; IN-SITU HYBRIDIZATION; C-ERBB-2 ONCOPROTEIN; HUMAN-BREAST; IMMUNOHISTOCHEMICAL DETECTION; HER-2/NEU ONCOPROTEIN; ONCOGENE EXPRESSION; NEU ONCOGENE; OVEREXPRESSION; CARCINOMAS;
Keywords:
HER-2/neu; c-erbB-2; FISH; fluorescence in situ hybridization; gene amplification; prostate cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Small, EJ Univ Calif San Francisco, Ctr Comprehens Canc, Urol Oncol Program, Div Hematol Oncol, 2356 Sutter St,5th Floor, San Francisco, CA 94115 USAUniv Calif San Francisco 2356 Sutter St,5th Floor San Francisco CA USA 94115
Citazione:
D.M. Reese et al., "HER2 protein expression and gene amplification in androgen-independent prostate cancer", AM J CLIN P, 116(2), 2001, pp. 234-239

Abstract

The role of the HER2 receptor remains uncertain in the pathogenesis and progression of human prostate cancer. Previous studies have reported widely, divergent rates for HER2 expression in primary prostate tumors, probably owing to significant methodologic differences in the studies. Few data exist about the frequency of HER2 protein overexpression and gene amplification in androgen-independent prostate cancer (AIPC) although recent xenograft models suggest HER2 expression may be up-regulated in the transition from androgen-dependent to androgen-independent disease. We studied the role of HER2protein in AIPC by, immunohistochemical and fluorescence in situ hybridization (FISH) anal,ses on AIPC specimens using well-characterized and validated reagents. Fourteen (36%) of 39 specimens expressed HER2; however, only, 2 (5%) had moderate (2+) expression, and 2 (5%) had high-level (3+) expression. Two (6%) of 36 specimens had gene amplification by FISH. These data suggest that HER2 protein overexpression and gene amplification are relatively, uncommon in AIPC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:31:36