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Titolo:
The inflamed plaque: Cytokine production and cellular cholesterol balance in the vessel wall
Autore:
Fazio, S; Linton, MF;
Indirizzi:
Vanderbilt Univ, Sch Med, Dept Med, Div Cardiovasc Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 ovasc Med, Nashville, TN 37232 USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 2A, volume: 88, anno: 2001,
pagine: 12E - 15E
SICI:
0002-9149(20010719)88:2A<12E:TIPCPA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING CASSETTE TRANSPORTER-1; DENSITY-LIPOPROTEIN DEFICIENCY; NF-KAPPA-B; INTERFERON-GAMMA; TANGIER-DISEASE; ATHEROSCLEROTIC LESIONS; ENDOTHELIAL-CELLS; CD40 LIGAND; FOAM CELLS; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Fazio, S Vanderbilt Univ, Sch Med, Dept Med, Div Cardiovasc Med, 315 Med Res Bldg 2, Nashville, TN 37232 USA Vanderbilt Univ 315 Med Res Bldg 2 Nashville TN USA 37232 232 USA
Citazione:
S. Fazio e M.F. Linton, "The inflamed plaque: Cytokine production and cellular cholesterol balance in the vessel wall", AM J CARD, 88(2A), 2001, pp. 12E-15E

Abstract

Although the concept that inflammation plays a role in the biology of atherosclerosis is now well accepted, the basic feature of the arterial lesion remains the accumulation of clusters of foam cells. These clusters are the consequence of the enhanced recruitment of monocytes in the vessel wall induced by the hyperlipidemia and of the disproportionate accumulation of lipids in the cytoplasm of macrophages deriving from monocytes. Ultimately, every molecular force and pathway with modulating activity over the developinglesion will have ro act on a convergence point with factors regulating cholesterol balance in the macrophage. Consistent with this view is the recentreport that cytokines, such as tumor necrosis factor-alpha, can influence the expression of the scavenger receptor, whereas interferon-gamma can inhibit adenosine triphosphate-binding cassette transporter-1, the main effector of cholesterol efflux in the peripheral cell. Conversely, recent data have shown that primary alterations in macrophage cholesterol balance, such asthose produced by the total absence of acylcoenzyme A:cholesterol acyltransferase-1, may determine local changes compatible with the activation of inflammatory pathways. to this brief review, we discuss some of the convergence points between inflammation and cholesterol balance, and we highlight the additional therapeutic targets suggested by these new developments in vascular biology. (C) 2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:50:04