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Titolo:
Wound healing response in the presence of stromal irregularities after excimer laser treatment
Autore:
Weber, BA; Gan, L; Fagerholm, P;
Indirizzi:
Karolinska Inst, St Eriks Eye Hosp, Res Lab, S-11282 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-11282 Lab, S-11282 Stockholm, Sweden Linkoping Univ Hosp, Dept Ophthalmol, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 , S-58185 Linkoping, Sweden
Titolo Testata:
ACTA OPHTHALMOLOGICA SCANDINAVICA
fascicolo: 4, volume: 79, anno: 2001,
pagine: 381 - 388
SICI:
1395-3907(200108)79:4<381:WHRITP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL PHOTOREFRACTIVE KERATECTOMY; HYALURONIC-ACID; POLYMORPHONUCLEAR LEUKOCYTES; PHOTOTHERAPEUTIC KERATECTOMY; SUPERFICIAL KERATECTOMY; SURFACE ULTRASTRUCTURE; REFRACTIVE KERATECTOMY; MYOPIC REGRESSION; CORNEAL SURFACE; FOLLOW-UP;
Keywords:
rabbit cornea; dry mass; hyaluronan; microradiography; wound healing; surface irregularities; smoothness; excimer laser keratectomy; leukocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Weber, BA Karolinska Inst, St Eriks Eye Hosp, Res Lab, S-11282 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-11282 282 Stockholm, Sweden
Citazione:
B.A. Weber et al., "Wound healing response in the presence of stromal irregularities after excimer laser treatment", ACT OPHTH S, 79(4), 2001, pp. 381-388

Abstract

Purpose: To trace the fate of stromal irregularities after excimer laser treatment and to increase our knowledge of the reasons why surface irregularities in the ablation bed cause inferior postoperative results. Methods: Twelve New Zealand White rabbits received a transepithelial photoablation to a preset depth of 60 mum. An electron microscopy specimen grid was then placed on the denuded stroma and another 20 mum ablation was applied in order to produce surface irregularities. Another six rabbits receiveda plano transepithelial photoablation to a preset depth of 80 mum. The treated corneas were harvested at various timepoints and differentially further processed for microradiography, hematoxylin-eosin -, hyaluronan (HA)- andleukocyte protein L1 staining. Results: In the grid treated corneas the subepithelial mesh pattern is clearly discernible after 1 week, and after 4 weeks it is replaced by a subepithelial layer containing HA and water. The thinning of this layer between 1and 12 weeks is statistically significant (p<0.05). After 4 and 8 week theplano treated corneas only exhibit some subepithelial HA- and water accumulation. After 1 day the grid treated corneas show an extensive stromal infiltration of leukocytes. In the plano treated corneas the leukocytes mainly remain on the surface. Conclusions: During the healing process stromal irregularities are flattened, leaving a homogeneous zone with increased water content. This subepithelial layer is rarefying as new subepithelial tissue is forming. Postablational irregularities induce a more pronounced healing reaction when compared to a smooth ablation surface. Leukocyte infiltration seems to play a role in this process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:47:13