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Titolo:
Simultaneous management of blood flow and IOP in glaucoma
Autore:
Harris, A; Jonescu-Cuypers, C; Martin, B; Kagemann, L; Zalish, M; Garzozi, HJ;
Indirizzi:
Indiana Univ, Sch Med, Dept Ophthalmol, Indianapolis, IN 46202 USA IndianaUniv Indianapolis IN USA 46202 halmol, Indianapolis, IN 46202 USA Indiana Univ, Med Sci Program, Bloomington, IN USA Indiana Univ Bloomington IN USA iv, Med Sci Program, Bloomington, IN USA Kaplan Med Ctr, Dept Ophthalmol, Rehovot, Israel Kaplan Med Ctr Rehovot Israel Med Ctr, Dept Ophthalmol, Rehovot, Israel Haemek Med Ctr, Dept Ophthalmol, Afula, Israel Haemek Med Ctr Afula Israel mek Med Ctr, Dept Ophthalmol, Afula, Israel
Titolo Testata:
ACTA OPHTHALMOLOGICA SCANDINAVICA
fascicolo: 4, volume: 79, anno: 2001,
pagine: 336 - 341
SICI:
1395-3907(200108)79:4<336:SMOBFA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPTIC-NERVE HEAD; OPEN-ANGLE GLAUCOMA; NORMAL-TENSION GLAUCOMA; RETINAL GANGLION-CELLS; CARBONIC-ANHYDRASE INHIBITORS; HIGH INTRAOCULAR-PRESSURE; ISCHEMIC BRAIN-DAMAGE; NITRIC-OXIDE; AUTO-REGULATION; PERFUSION-PRESSURE;
Keywords:
carbonic anhydrase; intraocular pressure; ischemia; glaucoma;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, A Indiana Univ, Sch Med, Dept Ophthalmol, Rotary 134, Indianapolis, IN 46202USA Indiana Univ Rotary 134 Indianapolis IN USA 46202 s, IN 46202USA
Citazione:
A. Harris et al., "Simultaneous management of blood flow and IOP in glaucoma", ACT OPHTH S, 79(4), 2001, pp. 336-341

Abstract

Factors other than intraocular pressure (IOP) elevation must be involved in initiation and progression of glaucoma. An additional element in disease causation may be ischemia in the retina and optic nerve head. Ischemic damage to neurons in the CNS is similar mechanistically and histopathologicallyto changes seen in glaucoma. Further, glaucoma patients with normal IOP show clear evidence for cerebral and ocular ischemia. Aging and atherosclerosis reduce the ability of the eye to autoregulate blood flow when ocular perfusion pressure changes: the dependence of blood flow on perfusion pressurelinks ischemia to IOP. Consequently, neuroprotective treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:42:39