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Titolo:
Outcome of pregnancy in chromosomally normal fetuses with increased nuchaltranslucency in the first trimester
Autore:
Souka, AP; Krampl, E; Bakalis, S; Heath, V; Nicolaides, KH;
Indirizzi:
Univ London Kings Coll Hosp, Harris Birthright Res Ctr Fetal Med, London SE5 9RS, England Univ London Kings Coll Hosp London England SE5 9RS ndon SE5 9RS, England
Titolo Testata:
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
fascicolo: 1, volume: 18, anno: 2001,
pagine: 9 - 17
SICI:
0960-7692(200107)18:1<9:OOPICN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEMLI-OPITZ-SYNDROME; CONGENITAL HEART-DISEASE; 10-14 WEEKS GESTATION; SPINAL MUSCULAR-ATROPHY; 13 WEEKS GESTATION; 1ST-TRIMESTER DIAGNOSIS; PRENATAL-DIAGNOSIS; TRANSVAGINAL ULTRASONOGRAPHY; CYSTIC HYGROMA; SONOGRAPHIC DIAGNOSIS;
Keywords:
10-14-week scan; cardiac defects; fetal abnormalities; first trimester; genetic syndromes; nuchal translucency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Nicolaides, KH Univ London Kings Coll Hosp, Harris Birthright Res Ctr Fetal Med, Denmark Hill, London SE5 9RS, England Univ London Kings Coll Hosp Denmark Hill London England SE5 9RS
Citazione:
A.P. Souka et al., "Outcome of pregnancy in chromosomally normal fetuses with increased nuchaltranslucency in the first trimester", ULTRASOUN O, 18(1), 2001, pp. 9-17

Abstract

Objectives To study the outcome of chromosomally normal pregnancies with increased nucbal translucency at the 10-14-week scary. Design Retrospective stud), of 1320 chromosomally normal singleton pregnancies with nuchal translucency of greater than or equal to3.5 mm. In addition to fetal karyotyping these patients were managed with follow-up scans at 14-16 and 20-22 weeks, specialist fetal echocardiography and in selected cases by infection. screening and further genetic testing. Results In the 1320 pregnancies there were 68 (5.15%) spontaneous abortions or intrauterine deaths, 18 (1.36%) neonatal and infant deaths and 154 (11.67%) terminations of pregnancy. In the 1080 (81.82%) survivors, 60 (5.56%)had abnormalities requiring medical or surgical treatment or leading to mental handicap. The chance of a livebirth with, no defects in the group withnuchal translucency of 3.5-4.4 mm was 86%, for those with translucency of 4.5-5.4 mm it was 77%, for those with translucency of 5.5-6.4 mm it was 67%, and for those with translucency of greater than or equal to 6.5 mm it was31 %. Conclusions Increased fetal nuchal translucency, is associated with chromosomal abnormalities, many, fetal defects and genetic syndromes. In the majority of cases a series of antenatal investigations, including fetal karyotyping, detailed scans, fetal echocardiography, as well as genetic testing and infection screening, that cart be completed by 20 weeks of gestation would distinguish between the pregnancies destined to result in adverse outcomeand those leading to the delivery of infants without major defects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 20:06:40