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Titolo:
Vaccines for colorectal cancer
Autore:
Zeh, HJ; Stavely-OCarroll, K; Choti, MA;
Indirizzi:
Johns Hopkins Hosp, Div Surg Oncol, Dept Surg, Baltimore, MD 21287 USA Johns Hopkins Hosp Baltimore MD USA 21287 t Surg, Baltimore, MD 21287 USA Milton S Hershey Med Ctr, Dept Surg, Div Surg Oncol, Hershey, PA USA Milton S Hershey Med Ctr Hershey PA USA Div Surg Oncol, Hershey, PA USA
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 7, volume: 7, anno: 2001,
pagine: 307 - 313
SICI:
1471-4914(200107)7:7<307:VFCC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE-SPECIFIC IMMUNOTHERAPY; PULSED DENDRITIC CELLS; AUTOLOGOUS TUMOR-CELL; PROSPECTIVELY RANDOMIZED TRIAL; MONOCLONAL-ANTIBODY VACCINE; COLONY-STIMULATING FACTOR; GM-CSF GENE; PHASE-I; CARCINOEMBRYONIC ANTIGEN; IMMUNE-RESPONSES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Choti, MA Johns Hopkins Hosp, Div Surg Oncol, Dept Surg, 600 N Wolfe St,Halsted 614,Baltimore, MD 21287 USA Johns Hopkins Hosp 600 N Wolfe St,Halsted614 Baltimore MD USA 21287
Citazione:
H.J. Zeh et al., "Vaccines for colorectal cancer", TRENDS MO M, 7(7), 2001, pp. 307-313

Abstract

Despite recent advances in the treatment of colorectal cancer, the overallsurvival rate for those patients with advanced locoregional disease remains less than 50%. Although adjuvant systemic chemotherapy has improved survival of these patients, more effective therapies are needed. Immunotherapy is an approach that could have a particular role in the adjuvant therapy of colorectal cancer. There is now convincing evidence that the immune system can specifically recognize and destroy malignant cells. Although both antibody- and T-cell-mediated anti-tumor responses have been documented, the cellular immune response with its direct cytotoxic mechanisms is felt to be the principal anti-tumor arm of the immune system. Analysis of the T cells that recognize tumors has led to the identification and characterization of many tumor-associated antigens including several colorectal antigens. Current approaches to developing a vaccine for colorectal cancer use our expandedunderstanding of these tumor-associated antigens and the conditions that allow development of an effective cellular immune response to them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:30:40