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Titolo:
New light on polyglutamine neurodegenerative disorders: interference with transcription
Autore:
Neri, C;
Indirizzi:
CEPH, Fdn Jean Dausset, Lab Genom Biol, F-75010 Paris, France CEPH ParisFrance F-75010 Dausset, Lab Genom Biol, F-75010 Paris, France
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 7, volume: 7, anno: 2001,
pagine: 283 - 284
SICI:
1471-4914(200107)7:7<283:NLOPND>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREB-BINDING PROTEIN; HUNTINGTONS-DISEASE; EXPANDED POLYGLUTAMINE; MUTANT HUNTINGTIN; TRANSGENIC MICE; NEUROPATHOLOGY; LOCALIZATION; NUCLEAR; MODEL; DEATH;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Neri, C CEPH, Fdn Jean Dausset, Lab Genom Biol, 27 Rue Juliette Dodu, F-75010 Paris, France CEPH 27 Rue Juliette Dodu Paris France F-75010 5010 Paris, France
Citazione:
C. Neri, "New light on polyglutamine neurodegenerative disorders: interference with transcription", TRENDS MO M, 7(7), 2001, pp. 283-284

Abstract

There is accumulating evidence that aberrant transcriptional regulation isinvolved in neurodegenerative disorders associated with expanded polyglutamines, Recent work on the coactivator CREB-binding protein suggests that transcription factors containing a normal polyglutamine stretch might be redistributed to nuclear inclusions and cytoplasmic aggregates, resulting in cellular toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 03:01:32