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Titolo:
Synaptic vesicles: Is kissing a matter of competence?
Autore:
Valtorta, F; Meldolesi, J; Fesce, R;
Indirizzi:
Dept Neurosci, I-20132 Milan, Italy Dept Neurosci Milan Italy I-20132Dept Neurosci, I-20132 Milan, Italy Vita Salute Univ, San Raffaele Sci Inst, I-20132 Milan, Italy Vita Salute Univ Milan Italy I-20132 aele Sci Inst, I-20132 Milan, Italy
Titolo Testata:
TRENDS IN CELL BIOLOGY
fascicolo: 8, volume: 11, anno: 2001,
pagine: 324 - 328
SICI:
0962-8924(200108)11:8<324:SVIKAM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FROG NEUROMUSCULAR-JUNCTION; NERVE-TERMINALS; NEUROTRANSMITTER RELEASE; HIPPOCAMPAL SYNAPSES; FUSION; EXOCYTOSIS; MEMBRANE; TRANSMITTER; ENDOCYTOSIS; CLATHRIN;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Valtorta, F Dept Neurosci, Via Olgettina 58, I-20132 Milan, Italy Dept Neurosci Via Olgettina 58 Milan Italy I-20132 lan, Italy
Citazione:
F. Valtorta et al., "Synaptic vesicles: Is kissing a matter of competence?", TR CELL BIO, 11(8), 2001, pp. 324-328

Abstract

The `kiss-and-run` model of exocytosis and endocytosis predicts that synaptic vesicles can undergo fast and efficient recycling, after fusion with the plasmalemma,without intermixing of membranes. Evidence is mounting from several new experimental approaches that kiss-and-run occurs at synapses. Distinct vesicle pools, which initially were identified in morphological terms, are now being characterized in biochemical and functional terms. In addition, at least two functional recycling pathways, operating on different time scales (from milliseconds to tens of seconds, have been shown to coexistin the same synaptic system, and the two pathways appear to be differentially regulated. Taken together, these data suggest that kiss-and-run operates in parallel with the classical, coated-vesicle recycling. Here, we reviewrecent evidence for kiss-and-run recycling and discuss whether it is a distinct process, dependent on the molecular organization of the fusing vesicle. We propose that vesicles undergo a process of `competence maturation' According to this view, the specific molecular make-up of the vesicles,their location and their interactions with nerve terminal proteins might determine not only the differential availability of the vesicles for fusion and neurotransmitter release but also the recycling path that they will follow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:10:25