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Titolo:
Effects of thyroid hormones on cardiac structure: A tissue characterization study in patients with thyroid disorders before and after treatment
Autore:
Ciulla, MM; Paliotti, R; Cortelazzi, D; Tortora, G; Barelli, MV; Buonamici, V; Magrini, F; Beck-Peccoz, P;
Indirizzi:
Univ Milan, Osped Maggiore Policlin, Ctr Fisiol Clin & Ipertens, IRCCS,Inst Internal Med, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 S,Inst Internal Med, I-20122 Milan, Italy Univ Milan, Osped Maggiore Policlin, IRCCS, Inst Endocrine Sci, Milan, Italy Univ Milan Milan Italy oliclin, IRCCS, Inst Endocrine Sci, Milan, Italy
Titolo Testata:
THYROID
fascicolo: 7, volume: 11, anno: 2001,
pagine: 613 - 619
SICI:
1050-7256(200107)11:7<613:EOTHOC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC DILATED CARDIOMYOPATHY; VENTRICULAR MYOCARDIUM; QT DISPERSION; COLLAGEN GENE; L-THYROXINE; FIBROSIS; HEART; HYPERTROPHY; FIBROBLASTS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ciulla, MM Univ Milan, Osped Maggiore Policlin, Ctr Fisiol Clin & Ipertens, IRCCS,Inst Internal Med, Via F Sforza 35, I-20122 Milan, Italy Univ MilanVia F Sforza 35 Milan Italy I-20122 22 Milan, Italy
Citazione:
M.M. Ciulla et al., "Effects of thyroid hormones on cardiac structure: A tissue characterization study in patients with thyroid disorders before and after treatment", THYROID, 11(7), 2001, pp. 613-619

Abstract

Experimental evidence suggests an involvement of thyroid hormones in myocardial nonmyocyte component growth. We evaluated the possible role of thyroid hormones in myocardial remodeling by ultrasonic tissue characterization (videodensitometry) in 8 hyperthyroid patients, in 10 hypothyroid patients, and in 2 patients with thyroid hormone resistance syndrome (RTH), before, 60, and 120 days after treatment (TO, T60, T120), and in 10 age-matched euthyroids. According to a previously described procedure, the derived collagenvolume fraction (dCVF%, an echocardiographic index estimating the collagencontent) was predicted from the pixel-level frequency distribution width (broadband, Bb) of the selected echocardiographic images. Thyrotropin (TSH),fret thyroxine (FT4), and free triiodothyronine (FT3) were assessed by immunometric method. QT interval dispersion (QTd) on basal electrocardiogram was measured as a marker of dyshomogeneous ventricular repolarization. At TO, Bb and dCVF% were normal in hyperthyroid and euthyroid patients, and slightly increased in RTH patients, whereas significantly higher values were found in hypothyroids. At T60, a significant reduction in Bb was observed in hypothyroids, with nearly normal dCVF% values. This trend was confirmed at T120 with complete normalization of echoreflectivity. No echoreflectivity changes were observed in hyperthyroid and RTH patients during treatment. QTdwas significantly increased in hypothyroids at TO, while no significant differences were found among groups at T60 and T120. Because the different videodeonsitometric myocardial properties observed in hypothyroid versus hyperthyroid patients correspond to an increase of dCVF%, this study suggests that thyroid hormones exert an inhibitory effect on myocardial collagen synthesis in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:53:56