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Titolo:
E-cadherin complex and its abnormalities in human breast cancer
Autore:
Jiang, WG; Mansel, RE;
Indirizzi:
Univ Wales, Coll Med, Dept Surg, Metastasis Res Grp, Cardiff CF14 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF14 4XN Cardiff CF14 4XN, S Glam, Wales
Titolo Testata:
SURGICAL ONCOLOGY-OXFORD
fascicolo: 4, volume: 9, anno: 2000,
pagine: 151 - 171
SICI:
0960-7404(200012)9:4<151:ECAIAI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL ADHESION; TUMOR-SUPPRESSOR PROTEIN; BETA-CATENIN EXPRESSION; SEGMENT POLARITY GENE; CARCINOMA IN-SITU; FAVORABLE PROGNOSTIC FACTORS; TYROSINE KINASE SUBSTRATE; GAMMA-LINOLENIC ACID; MOLECULE E-CADHERIN; ALPHA-CATENIN;
Keywords:
E-cadherin; catenin; breast cancer; metastasis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
187
Recensione:
Indirizzi per estratti:
Indirizzo: Jiang, WG Univ Wales, Coll Med, Dept Surg, Metastasis Res Grp, Heath Pk, Cardiff CF14 4XN, S Glam, Wales Univ Wales Heath Pk Cardiff S Glam Wales CF14 4XN S Glam, Wales
Citazione:
W.G. Jiang e R.E. Mansel, "E-cadherin complex and its abnormalities in human breast cancer", SURG ONCOL, 9(4), 2000, pp. 151-171

Abstract

E-cadherin and its adhesion complex play an essential role in the adhesionof breast cancer cells and tissues. Members of the complex, such as beta -catenin, act as regulators on cell adhesion, and are involved in cell signalling and transcription regulation. The adhesion complex is a known structure in the control of tumour progression and metastasis. Recent years have seen a rapid expansion in the understanding of the biology and clinical relevance of the complex in breast cancer. The current article summarises recent progresses in the molecular/cellular biology of E-cadherin and its complex and the clinical, diagnostic, prognostic, and therapeutic value of this complex in breast cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:55:09