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Titolo:
Impact of treatment acceleration and its timing on the response of the rhabdomyosarcoma R1H of the rat to fractionated irradiation
Autore:
Raabe, A; Quaester, S; Dubben, HH; Zieron, JO; Krull, A; Alberti, W; Beck-Bornholdt, HP;
Indirizzi:
Univ Hamburg, Abt Strahlentherapie & Radioonkol, Hamburg, Germany Univ Hamburg Hamburg Germany lentherapie & Radioonkol, Hamburg, Germany Univ Hamburg, Inst Biophys & Strahlenbiol, Hamburg, Germany Univ Hamburg Hamburg Germany t Biophys & Strahlenbiol, Hamburg, Germany Med Univ Lubeck, Klin Kiefer & Gesichtschirurg, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 schirurg, D-23538 Lubeck, Germany
Titolo Testata:
STRAHLENTHERAPIE UND ONKOLOGIE
fascicolo: 7, volume: 177, anno: 2001,
pagine: 362 - 366
SICI:
0179-7158(200107)177:7<362:IOTAAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONCOMITANT BOOST; TREATMENT TIME; RADIOTHERAPY; CARCINOMA; KINETICS;
Keywords:
fractionation; boost; dose intensity; tumor; rhabdomyosarcoma; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Raabe, A Univ Hamburg, Hosp Eppendorf, Abt Strahlentherapie & Radioonkol, Radiol Klin, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 burg, Germany
Citazione:
A. Raabe et al., "Impact of treatment acceleration and its timing on the response of the rhabdomyosarcoma R1H of the rat to fractionated irradiation", STRAH ONKOL, 177(7), 2001, pp. 362-366

Abstract

Background and Purpose: In clinical practice a concomitant boost is usually given as a second daily dose to a reduced field. The question arises which part of treatment should be accelerated to achieve optimal tumor control. An experiment was performed on tumor bearing rats to determine the optimaltiming of treatment acceleration for this experimental tumor system. Material and Methods: Rhabdomyosarcoma R1H of the rat were treated applying 30 fractions in an overall treatment time of 40-42 days, Up to total doses ranging from 67.5 to 97.5 Gy were administered. For control a standard treatment was given as continuous treatment applying one fraction per day. A boost of five additional fractions was given as a second fraction during 5 days. Three experimental arms received a boost either in the 1st, 4th, or in the last week of treatment. Treatment outcome was assessed using tumor control as endpoint. Results: All experimental arms proved more effective than the standard treatment. Treatment was most effective when the boost was administered in the1st week of treatment. A TCD37% of 87.1 Gy (95% CI: 82.8...92.7 Gy), 96.5 Gy (89.9...107.1), and 107.3 Gy (97.2...131.0) was determined, when the boost was given in the 1st, 4th, or last week of treatment, respectively. The observed difference between the experimental arms was statistically significant (p = 0.004). Conclusions: Initially accelerated treatment schedules were found to be more effective for tumor control in an experimental tumor system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:20:41