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Titolo:
CD34(-) blood-derived human endothelial cell progenitors
Autore:
Harraz, M; Jiao, CH; Hanlon, HD; Hartley, RS; Schatteman, GC;
Indirizzi:
Univ Iowa, Dept Anat & Cell Biol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 nat & Cell Biol, Iowa City, IA 52242 USA
Titolo Testata:
STEM CELLS
fascicolo: 4, volume: 19, anno: 2001,
pagine: 304 - 312
SICI:
1066-5099(2001)19:4<304:CBHECP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; GROWTH-FACTOR RECEPTORS; IN-VIVO; DIABETIC MICE; NEOVASCULARIZATION; ANGIOGENESIS; DIFFERENTIATION; MONOCYTES; ENDOGLIN; ORIGIN;
Keywords:
stem cells; endothelial cell; angiogenesis; CD34; monocyte; CD14;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schatteman, GC Univ Iowa, Dept Anat & Cell Biol, BSB 1402, Iowa City, IA 52242 USA Univ Iowa BSB 1402 Iowa City IA USA 52242 ity, IA 52242 USA
Citazione:
M. Harraz et al., "CD34(-) blood-derived human endothelial cell progenitors", STEM CELLS, 19(4), 2001, pp. 304-312

Abstract

A subset of adult peripheral blood leukocytes functions as endothelial cell progenitors called angioblasts, They can incorporate into the vasculaturein animal models of neovascularization and accelerate the restoration of blood flow to mouse ischemic limbs. Earlier reports suggested that CD34-expressing (CD34(+)) but not CD34(+) cell-depleted (CD34(-)) leukocytes can differentiate into endothelial cells (EC) in vitro and in vivo. Recent findings suggest that CD14(+) cells, which are typically CD34(-), also have angioblast-like properties in vitro. To determine the identity of angioblasts, the potential of CD34(+), CD34(-), CD34(-)CD14(+), and CD34(-)CD14(-) cells to produce EC was compared. We show that a subset of monocyte (CD34(-)CD14(+))-enriched cells can take on an EC-like phenotype in culture, but that theEC-like cells also express dendritic cell antigens, These findings suggestthat monocytes differentiate into macrophages, dendritic cells, or EC depending on environmental cues. The data also demonstrate that angioblasts aremore abundant in the blood than previously thought. Finally, we demonstrate that CD34(-) and CD34(-)CD14(+) cells incorporate into the endothelium ofblood vessels in mouse ischemic limbs. However, incorporation of these cells requires co-injection with CD34(+) cells, indicating that leukocyte-leukocyte interactions may play a critical role in governing angioblast behavior in vivo.

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Documento generato il 29/09/20 alle ore 23:16:35