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Titolo:
Course of chronic focal epilepsy resistant to anticonvulsant treatment
Autore:
Bauer, J; Burr, W;
Indirizzi:
Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 nn, Dept Epileptol, D-53105 Bonn, Germany
Titolo Testata:
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
fascicolo: 4, volume: 10, anno: 2001,
pagine: 239 - 246
SICI:
1059-1311(200106)10:4<239:COCFER>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATISTICAL-ANALYSIS; UNTREATED EPILEPSY; SEIZURE FREQUENCY; PROGNOSIS; REMISSION; CARBAMAZEPINE; POPULATION; RECURRENCE; MODELS;
Keywords:
focal seizures; course of epilepsy; treatment prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, J Univ Bonn, Klin Epileptol, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 onn, Germany
Citazione:
J. Bauer e W. Burr, "Course of chronic focal epilepsy resistant to anticonvulsant treatment", SEIZURE-E J, 10(4), 2001, pp. 239-246

Abstract

Sixty-three patients (32 women, 31 men), chronically treated with carbamazepine, phenytoin, valproate and/or phenobarbital, were investigated. Mean age at manifestation of epilepsy was 16.4 years; mean age at onset of documentation of seizure frequency was 33.7 years; mean duration of follow-up was104.8 months; mean number of documented seizures per patient was 313.2. A statistical analysis of seizure diaries was performed. For each day the entries were the number of seizures per day. Linear trends, the amount of variance of the seizure frequency compared to randomly distributed events, werecomputed with the resulting coefficients fitting a general linear regression model. Non-random aggregations (clusters) were searched for as well as gaps of seizure manifestation. A similar number of patients exhibited a decrease (30%) or increase (29%) of seizure frequency during the course of epilepsy. The variance of the daily seizure frequency was in most patients (78%) significantly higher or lower (5%) than corresponding random distributions. The coupling coefficient to the day before was significantly larger thanzero (indicating seizure clustering) in 57% of patients. Significant rhythmic components in seizure profiles (quasi-weekly or quasi-monthly) were found in 31 patients (both male and female). Periods of increased seizure frequency (clusters) manifested in 62% of patients; seizure gaps of at least 1 year occurred in 29 patients followed by seizure relapses in 20 patients. In conclusion, there is no evidence for a unique type of course in chronic focal epilepsy in patients on antiepileptic drugs. (C) 2001 BEA Trading Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:00:55