Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Helicobacter pylori eradication versus one-year maintenance therapy: effect on relapse and gastritis outcome
Autore:
Mones, J; Rodrigo, L; Sancho, F; Martin, L; Boixeda, D; Artes, MT; Garcia-Cases, C;
Indirizzi:
Hosp Santa Creu & Sant Pau, Barcelona, Spain Hosp Santa Creu & Sant Pau Barcelona Spain & Sant Pau, Barcelona, Spain
Titolo Testata:
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
fascicolo: 6, volume: 93, anno: 2001,
pagine: 381 - 389
SICI:
1130-0108(200106)93:6<381:HPEVOM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUODENAL-ULCER PATIENTS; WEEK TRIPLE-THERAPY; PEPTIC-ULCER; FOLLOW-UP; DOUBLE-BLIND; BREATH TEST; REINFECTION RATE; UNITED-STATES; DRUG-THERAPY; RECURRENCE;
Keywords:
ulcer relapse; gastritis; omeprazole; H. pylori eradication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Artes, MT Pharma Consult Serv SA, Travesear Gracia 17-21 1o 5a, Barcelona 08029, Spain Pharma Consult Serv SA Travesear Gracia 17-21 1o 5a BarcelonaSpain 08029
Citazione:
J. Mones et al., "Helicobacter pylori eradication versus one-year maintenance therapy: effect on relapse and gastritis outcome", REV ESP E D, 93(6), 2001, pp. 381-389

Abstract

Objective: the aim of this study was to determine ulcer healing and H. pylori eradication rates obtained with triple therapy (omeprazole, amoxicillinand clarithromycin). Ulcer relapsing rate one year after eradication was also assessed. Maintenance therapy with placebo was compared with ranitidinetherapy and the effect of eradication on histological variables of the gastric mucosa was studied. Methods: a prospective, double-blind parallel study was performed in 85 patients endoscopically diagnosed of duodenal ulcer H. pylori positive. Patients were randomized to a 7-days triple therapy (group A) or omeprazole plusantibiotic placebo (group B). All patients were treated only with omeprazole for the next three weeks. Patients with ulcer healing after treatment were entered in a one-year follow up phase with ranitidine placebo (group A) or ranitidine (group B). Endoscopy and biopsies were performed at baseline,after treatment (5 weeks) and after 12 months of follow-up or when relapsing symptoms appeared. Results: healing rate was 90.2% in group A and 85.7% in group B. Eradication rate was 78% in group A and 0% in group B, Out of 37 healed patients in group A, eradication was achieved in 29 and only one relapse was found (3.4%). Three out of eight patients with healing but without eradication relapsed at 12 months (35%) (p<0.05). Histopathological results showed statistically significant differences (p<0.05) between eradicated and non eradicated patients in terms of severity of inflammation and intestinal metaplasia, but not in terms of atrophy. Conclusions: H. pylori eradication is useful to prevent ulcer relapse and to improve gastric mucosa status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 14:59:20