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Titolo:
Postoperative analgesia by intraarticular clonidine and neostigmine in patients undergoing knee arthroscopy
Autore:
Gentili, M; Enel, D; Szymskiewicz, O; Mansour, F; Bonnet, F;
Indirizzi:
Hop Tenon, Assistance Publ Hop Paris, Dept Anesthesia & Intens Care, F-75970 Paris 20, France Hop Tenon Paris France 20 thesia & Intens Care, F-75970 Paris 20, France Ctr Med Chirurg St Vincent, Rennes, France Ctr Med Chirurg St Vincent Rennes France urg St Vincent, Rennes, France
Titolo Testata:
REGIONAL ANESTHESIA AND PAIN MEDICINE
fascicolo: 4, volume: 26, anno: 2001,
pagine: 342 - 347
SICI:
1098-7339(200107/08)26:4<342:PABICA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRATHECAL NEOSTIGMINE; PERIPHERAL ANALGESIA; NITRIC-OXIDE; SPINAL-CORD; MORPHINE; COMBINATION; SURGERY; SHEEP; AGONISTS; RECEPTOR;
Keywords:
postoperative analgesia; arthroscopic knee surgery; alpha-2-adrenergic agonists : clonidine; acetylcholinesterase inhibitor : neostigmine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bonnet, F Hop Tenon, Dept Anesthesiol Reanimatol, 4 Rue Chine, F-75970 Paris 20, France Hop Tenon 4 Rue Chine Paris France 20 F-75970 Paris 20, France
Citazione:
M. Gentili et al., "Postoperative analgesia by intraarticular clonidine and neostigmine in patients undergoing knee arthroscopy", REG ANES PA, 26(4), 2001, pp. 342-347

Abstract

Background and Objective: Clonidine and neostigmine have a central mechanism of analgesic action and are synergistic when given intrathecally. Both drugs also have a peripheral analgesic effect. The purpose of this study wasto compare the analgesic effect of intraarticular clonidine and neostigmine, used separately and in combination, in patients undergoing knee arthroscopy. Methods: Eighty-four American Society of Anesthesiologists (ASA) I and II patients scheduled for meniscus repair under arthroscopy were allocated randomly in 6 groups to receive in a double-blind manner at the end of surgery150 mug of intraarticular clonidine with subcutaneous saline, 500 mug of intraarticular neostigmine with subcutaneous saline, an intraarticular combination of 150 mug of clonidine and 500 mug of neostigmine with subcutaneoussaline, 150 mug of intraarticular clonidine with 500 mug of subcutaneous neostigmine, 500 Ag of intraarticular neostigmine with 150 mug of subcutaneous clonidine, or intraarticular and subcutaneous isotonic saline. Postoperative pain scores were measured on a visual analog scale (VAS) at rest and on mobilization. Paracetamol (I g) was given as a rescue medication when pain score was greater than 40. Results: VAS scores at rest and on mobilization were lower in the first 5 groups compared with the intraarticular saline group (P < .05), but no significant difference was documented between the treated groups. The time to the first paracetamol administration was shorter in the saline group compared with the other groups, and the paracetamol demand was also higher in thisgroup. Forty-five percent of the patients who had received clonidine had at least I episode of hypotension versus 4% of those who did not (P < .01). The incidence of bradycardia was 20% and 0%, respectively (P = .01). The incidence of nausea was not statistically different in patients who did and did not receive neostigmine (43% v 36%, respectively). Conclusion: Intraarticular administration of 150 mug of clonidine, 500 Ag of neostigmine, or both produce postoperative analgesia, and the combination is not more effective.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:23:57