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Titolo:
Effects of gabapentin in acute inflammatory pain in humans
Autore:
Werner, MU; Perkins, FM; Holte, K; Pedersen, JL; Kehlet, H;
Indirizzi:
Univ Copenhagen, Hvidovre Hosp, Dept Anesthesiol 532, Acute Pain Serv, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 Serv, DK-2650 Hvidovre, Denmark Univ Copenhagen, Hvidovre Hosp, Dept Surg Gastroenterol, DK-2650 Hvidovre,Denmark Univ Copenhagen Hvidovre Denmark DK-2650 terol, DK-2650 Hvidovre,Denmark Univ Rochester, Dept Anesthesiol, Rochester, NY 14627 USA Univ Rochester Rochester NY USA 14627 nesthesiol, Rochester, NY 14627 USA
Titolo Testata:
REGIONAL ANESTHESIA AND PAIN MEDICINE
fascicolo: 4, volume: 26, anno: 2001,
pagine: 322 - 328
SICI:
1098-7339(200107/08)26:4<322:EOGIAI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; POSTOPERATIVE PAIN; INTRATHECAL GABAPENTIN; NEUROPATHIC PAIN; RAT MODEL; AMITRIPTYLINE; HYPERALGESIA; ALLODYNIA; EFFICACY; MORPHINE;
Keywords:
acute pain; allodynia; anticonvulsants; gabapentin; hyperalgesia; thermal injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Werner, MU Univ Copenhagen, Hvidovre Hosp, Dept Anesthesiol 532, Acute Pain Serv, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 50 Hvidovre, Denmark
Citazione:
M.U. Werner et al., "Effects of gabapentin in acute inflammatory pain in humans", REG ANES PA, 26(4), 2001, pp. 322-328

Abstract

Background and Objectives: The aim of the study was to examine the analgesic effects of the anticonvulsant, gabapentin, in a validated model of acuteinflammatory pain. Methods: Twenty-two volunteers were investigated in a double-blind, randomized, placebo-controlled crossover study. Gabapentin 1,200 mg or placebo was given on 2 separate study days. Three hours after drug administration, a first-degree burn injury was produced on the medial aspect of the nondominant calf (12.5 cm(2), 47 degreesC for 7 minutes). Quantitative sensory testing (QST) included pain ratings to thermal and mechanical stimuli (visual analog scale [VAS]), assessments of thermal and mechanical detection thresholds, and areas of secondary hyperalgesia. Side effects drowsiness and postural instability were assessed by subjective ratings (VAS). Results: The burn injury induced significant primary and secondary hyperalgesia (P < .0001). Gabapentin diminished the decrease in mechanical pain threshold in the burn area (P = .04) and reduced secondary hyperalgesia, but the reduction was not significant (P = .06). Heat pain thresholds, pain during the burn, and mechanical pain in the area of secondary hyperalgesia were not significantly changed by gabapentin (P < .2). Ratings of drowsiness and unsteadiness during walking were significantly higher for gabapentin than for placebo (P < .05). Conclusions: The study indicates that gabapentin has no analgesic effect in normal skin, but may reduce primary mechanical allodynia in acute inflammation following a thermal injury. These observations suggest a clinical potential of gabapentin in the treatment of postoperative pain.

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Documento generato il 02/04/20 alle ore 13:06:43