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Titolo:
Strategies of hypoxia and anoxia tolerance in cardiomyocytes from the overwintering common frog, Rana temporaria
Autore:
Currie, S; Boutilier, RG;
Indirizzi:
Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England Univ Cambridge Cambridge England CB2 3EJ ool, Cambridge CB2 3EJ, England
Titolo Testata:
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
fascicolo: 3, volume: 74, anno: 2001,
pagine: 420 - 428
SICI:
1522-2152(200105/06)74:3<420:SOHAAT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEINS; METABOLIC-RATE; MOLECULAR CHAPERONES; CARDIAC MYOCYTES; TRANSGENIC MICE; MITOCHONDRIA; OXYGEN; CELLS; HEPATOCYTES; DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Currie, S Mt Allison Univ, Dept Biol, Sackville, NB E4L 1G7, Canada Mt Allison Univ Sackville NB Canada E4L 1G7 NB E4L 1G7, Canada
Citazione:
S. Currie e R.G. Boutilier, "Strategies of hypoxia and anoxia tolerance in cardiomyocytes from the overwintering common frog, Rana temporaria", PHYSIOL B Z, 74(3), 2001, pp. 420-428

Abstract

Using ventricular cardiomyocytes of the common frog, Rana temporaria, we investigated the metabolic strategies employed by the heart to tolerate 4 moof hypoxic submergence (overwintering) as well as acute bouts of anoxia. In contrast to what is observed for the whole animal, there was no change inoxygen consumption in cardiomyocytes isolated from normoxic frogs comparedwith those isolated from 4-mo hypoxic animals. Furthermore, cells from both normoxic and hypoxic frogs were able to completely recover oxygen consumption following 30 min of acute anoxia. From estimates of ATP turnover, it appears that frog cardiomyocytes are capable of a profound, completely reversible metabolic depression, such that ATP turnover is reduced by >90% of control levels during anoxia but completely recovers with reoxygenation. Moreover, this phenomenon is also observed in frogs that have been subjected to4 mo of extended hypoxia. We found a significant increase in the stress protein, hsp70, after 1 mo of hypoxic submergence, which may contribute to the heart's remarkable hypoxia and anoxia tolerance and may act to defend metabolism during the overwintering period.

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Documento generato il 22/01/20 alle ore 21:48:33